外用利巴韦林气雾剂联合思密达治疗小儿手足口病口腔溃疡的效果观察

Effect observation of Ribavirin Aerosol combined with external use of Smecta in treatment of oral ulcer in children with hand-foot-mouth disease

目的探讨外用利巴韦林气雾剂联合思密达治疗小儿手足口病口腔溃疡的效果。方法选择200例手足口病口腔溃疡的患儿,随机将其分成两组,治疗组102例,对照组98例,治疗组采用外用利巴韦林气雾剂联合思密达治疗,对照组采用碘甘油外用,两组患儿同时给予热毒宁和利巴韦林静脉滴注治疗,观察两组患儿手足口病口腔溃疡的治疗效果。结果治疗组显效96例,有效4例,有效率98.04%;对照组显效70例,有效8例,有效率79.59%。两组比较,差异有统计学意义(P<0.01)。两组治疗方法均未发生明显不良反应。结论外用利巴韦林气雾剂联合思密达治疗小儿手足口病口腔溃疡可速净病毒,保护溃疡面,促进溃疡愈合,且无不良反应,同时具有临床易操作,依从性高的特点,值得推广使用。

Objective To investigate the effect of Ribavirin Aerosol combined with external use of Smecta in treatment of oral ulcer on children with hand - foot - mouth disease. Methods Totally 200 cases of children with hand - foot - mouth disease with oral ulcer were randomly divided into treatment group for 102 cases, control group for 98 cases. Pa- tients in treatment group were givien Ribavirin Aerosol combined with external use of Smecta. Patients in control group were given Iodine Glycerol. The treatment effect of children with hand - foot - mouth disease in two groups were ob- served. Results Curative effect of treatment group （ 98.04% ） was significantly better than that of control group （79. 59% ） ; There was no adverse reaction happened among the two groups. Conclusion Ribavirin Aerosol combined with external use of Smecta in treatment of oral ulcer on children with hand - foot - mouth disease can accelerate ulcer healing and improve appetite. No adverse reaction is found in therapeutic process, and it has good compliance for chil- dren, so it is worthly of children popularization and application.