摘要
以酒石酸为拆分剂,从外消旋2-氨基丁醇中拆分出(D)-2-氨基丁醇和(L)-2-氨基丁醇。考察了不同的溶剂对2-氨基丁醇拆分的影响,最终选取了正丁醇作为拆分溶剂。并对反应时间,反应温度,溶剂体积对拆分的影响进行了考察。在最优条件下,D-2-氨基丁醇的总收率达到83.69%,旋光达到9.9°。
D-2-amino-butanol and L-2-amino-butanol were separated from the DL-2-amino-butanol by the tartaric acid as the resolving agent. The effects of different solvent on the separation of 2-amino-butanol were investigated. Finally, butyl alcohol was chosen as the split solvent. The effects of reaction time, reaction temperature, and volume of solvent were also investigated. Under the optimized conditions, the final yield of D-2-amino-butanol was 83. 69% and polarimetry was 9. 9 °.
出处
《广州化工》
CAS
2014年第24期82-84,113,共4页
GuangZhou Chemical Industry
关键词
2-氨基丁醇
酒石酸
旋光
拆分
2-amino-butanol
tartaric acid
solubility
polarimetry
