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紫绀型先天性心脏病患者血红蛋白增高的临床意义 被引量:4

Clinical significance of high hemoglobin in patients with cyanotic congenital heart disease
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摘要 目的:探讨紫绀型先天性心脏病(CHD)患者血红蛋白增高的临床意义。方法:将91例紫绀型CHD按血红蛋白值随机分为A组(180-200g/L)、B组(200-220g/L)及C组(〉220g/L),分析各组临床病理数据之间的相关性。结果:在血红蛋白增高患者中原发病为肺血减少型先天性心脏病的占81.32%。法洛四联症患者McGoon值与血红蛋白计数呈正性相关(P〈0.01)。A组体-肺侧支阳性例数较C组高(P〈0.01)。血红蛋白计数与红细胞压积、凝血酶原时间和国际化标准值呈正性线性关系(P〈0.01),与血小板计数呈负性线性关系(P〈0.01)。19例患者尿蛋白异常,占21.11%,3组间尿蛋白检测结果无差异(P〉0.05)。结论:紫绀型先天性心脏病患者血红蛋白增高与原发病、肺血管和侧支情况有关,可伴有血液系统、凝血功能和肾功能异常。 Objective:To discuss the clinical significance of high hemoglobin(HGB)in patients with cyanoticcongenital heart disease(CHD).Methods:Ninety-one patients with cyanotic CHD were randomly divided into group A(HGB 180-200g/L),B(HGB 200-220g/L)and C(HGB〉220g/L).The clinicopathologic data were statistically analyzed among three groups.Results:Congenital heart disease with diminutive pulmonary blood flow was the main primary disease for high hemoglobin,accounted for 81.32%.Positive correlation between McGoon value and hemoglobin in TOF patients was confirmed(P〈0.01).Compared with group C,patients in group A had higher positive rate of aorto-pulmonary collateral arteries(APCAs)(P〈0.05).There was positive linear correlation between hemoglobin and HCT,PT and INR(P〈0.01)and negative linear correlation between hemoglobin and PLT(P〈0.01).Nineteen patients were diagnosed as proteinuria,accounted for 21.11%,and there was no statistical difference in urinalysis among three groups(P〉0.05).Conclusion:The high hemoglobin in cyanotic CHD patients may be related with primary disease,pulmonary vessels and APCAs,probably with abnormal coagulation,hematopoietic system and renal function.
出处 《西北国防医学杂志》 CAS 2014年第4期326-328,共3页 Medical Journal of National Defending Forces in Northwest China
基金 广州市科技计划资助项目(2011J4100021) 天普研究基金资助项目(01201122)
关键词 先天性心脏病 紫绀 血红蛋白 Congenital heart disease Cyanosis Hemoglobin
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