急性脑梗死与颈动脉硬化斑块及C反应蛋白的相关性

Correlation of acute cerebral infarction and carotid atherosclerotic plaque and the level of C-reactive protein

目的:探讨急性脑梗死与颈动脉粥样硬化斑块及血清C反应蛋白(CRP)之间的相互关系。方法:应用彩色多普勒超声检测仪对68例住院的急性脑梗死患者(脑梗死组)及68例同期门诊健康体检者(对照组)进行颈动脉超声检查,观测颈动脉内膜-中层厚度(IMT)、粥样斑块类型,同时检测血清CRP水平。结果:脑梗死组血清CRP、颈动脉IMT及粥样硬化斑块检出率较对照组明显增加(P<0.05);脑梗死组不稳定性斑块、稳定性斑块及无斑块组血清CRP水平差异有统计学意义(P<0.05);高CRP组的脑梗死患者神经功能评分、致残率和死亡率均明显高于低CRP组,差异均有统计学意义(P<0.05)。结论:颈动脉IMT、粥样硬化斑块类型、血清CRP与急性脑梗死关系密切,CRP能间接反映颈动脉粥样硬化的程度及粥样硬化斑块的稳定性,是脑梗死病情轻重和预测预后的有效指标。

Objective： To investigate the correlation of acute cerebral infarction and carotid atherosclerotic plaque and serum C-reactive protein（ CRP）. Methods： 68 patients with acute cerebral infarction（ the cerebral infarction group） and 68 health examiners（ the control group） was selected. Carotid intima-media thickness（ IMT）,plaque type and the serum CRP levels were detected by the color doppler ultrasound and automatic biochemical analyzer. Results： The serum CRP levels,carotid IMT and the checking rate of carotid plaque were significantly higher in the cerebral infarction group than the control group（ P 〈 0. 05）; the serum CRP level of cerebral infarction group with unstable plaque,stability plaque and no plaque was significantly different（ P 〈 0. 05）;nerve function,disability rate and mortality of cerebral infarction group with high CRP score were significantly higher than the low CRP group,the differences were statistically significant（ P 〈0. 05）. Conclusion： There was a close relationship between the carotid atherosclerotic plaque type,IMT,serum CRP level and acute cerebral infarction. CRP could indirectly reflect the stability degree of atherosclerotic plaque. Serum CRP level is an effective index for severity and prognosis of cerebral infarction.