期刊文献+

动态观察血乳酸对脓毒性休克患者预后评估的价值 被引量:5

下载PDF
导出
摘要 目的:探讨动脉血乳酸和早期乳酸清除率对脓毒性休克患者预后的临床意义。方法:对54例脓毒性休克患者分别于确诊时、确诊后6 h测定动脉血乳酸的浓度,计算早期乳酸清除率;以住院28 d患者是否存活为预后判断的标准,将患者分为死亡组(22例)和存活组(32例)。以6 h乳酸清除率的高低分为3组,A组(乳酸清除率≤10%)、B组(乳酸清除率10%~30%)、C组(乳酸清除率≥30%),比较3组患者病死率。结果:存活组确诊时、确诊后6 h动脉血乳酸浓度低于死亡组,差异具有统计学意义(P〈0.05),B组、C组病死率低于A组,差异具有统计学意义(P〈0.05)。结论:动态监测脓毒性休克患者动脉血乳酸变化具有重要的临床意义,乳酸浓度高以及早期乳酸清除率低的患者病死率高预后差,早期乳酸清除率可作为判断脓毒性休克患者预后的指标之一。
出处 《河南医学研究》 CAS 2014年第11期48-50,共3页 Henan Medical Research
  • 相关文献

参考文献4

二级参考文献29

  • 1王东浩.乳酸清除率评估重度脓毒症患者预后的临床分析[J].中国急救医学,2007,27(1):15-17. 被引量:96
  • 2Levy MM,Fink MP,Marshall JC,et al.2001 SCCM /ESICM /ACCP/ATS/SIS international sepsis definitions conference[J].Crit Care Med,2003,31(4):1250-1256.
  • 3Dellinger RP,Levy MM,Carlet JM,et al.Surviving sepsis campaign:international guidelines for management of severe sepsis and septic shock:2008[J].Intensive Care Med,2008,34(1):17-60.
  • 4Suárez-Santamaría M,Santolaria F,Pérez-Ramírez A,et al.Prognostic value of inflammatory markers (notably cytokines and procalcitonin),nutritional assessment,and organ function in patients with sepsis[J].Eur Cytokine Netw,2010,21(1):19-26.
  • 5Colleen AC,Erik BK,Chintan DM,et al.Comparison of severity of illness scoring systems in the prediction of hospital mortality in severe sepsis and septic shock[J].J Emerg Trauma Shock,2010,3(4):342-347.
  • 6Okorie ON,Dellinger P.Lactate:biomarker and potential therapeutic target[J].Crit Care Clin,2011,27(2):299-326.
  • 7Nguyen.Early lactate clearance is associated with biomarkers of inflammation,coagulation,apoptosis,organ dysfunction and mortality in severe sepsis and septic shock[J].J Inflammation,2010,7:6.
  • 8Nguyen HB,Rivers EP,Muzzin A,et al.Early lactate clearance is associated with improved outcome in severe sepsis and septic shock[J].Crit Care Med,2004,32(8):1637-1642.
  • 9Trzeciak S,Dellinger R.Serum lactic acid as a predictor of mortality in patients with infection[J].Intensive Care Med,2007,33(6):970-977.
  • 10Levraut J,Ichai C,Petit I,et al.Low exogenous lactate clearance as an early predictor of mortality in normolactatemic critically ill septic patients[J].Crit Care Med,2003,31(3):705-710.

共引文献59

同被引文献54

  • 1王东浩.乳酸清除率评估重度脓毒症患者预后的临床分析[J].中国急救医学,2007,27(1):15-17. 被引量:96
  • 2Bone RC, Balk RA, Cerra FB, et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine[ J ]. Chest, 1992. 101 (6) : 1644-1655.
  • 3Rangel-Frausto MS, Pittet D, Costigan M, et al. The natural history of the systemic inflammatory response syndrome (SIRS), a prospective study [ J ]. JAMA, 1995,273 (2) : 117-123.
  • 4Hollenberg SM. Vasopressor support in septic shock [ J ]. Chest, 2007, 132(5) : 1678-1687.
  • 5Lee SW, Hong YS, Park DW, et al. Lactic acidosis not hyperlactatemia as a predictor of in hospital mortality in septic emergency patients [ J ]. Emerg Med J, 2008,25 (10) : 659-665.
  • 6Tisherman SA, Barie P, Bokhari F, et al. Clinical practice guideline : endpoints of resuscitation [ J ]. J Trauma, 2004,57 (4) : 898-912.
  • 7Gando S, Kameue T, Nanzaki S, et al. Participation of tissue factor and thrombin in posttraumatic systemic inflammatory syndrome [ J ]. Crit Care Med, 1997, 25 ( 11 ) : 1820-1826.
  • 8Levraut J, Ciebiera JP, Chave S, et al. Mild hyperlactatemia in stable septic patients is due to impaired lactate clearance rather than overproduction [ J ]. Am J Respir Crit Care Med, 1998, 157 (4Pt 1) : 1021-1026.
  • 9Nguyen HB, Rivers EP, Knoblich BP, et al. Early lactate clearance is associated with improved outcome in severe sepsis and septic shock [ J ]. Crit Care Med, 2004, 32 (8) : 1637-1642.
  • 10Rivers E, Nguyen B, Havstad S, et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock [ J ]. N Engl J Med, 2001,345 (19) : 1368-1377.

引证文献5

二级引证文献29

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部