肥大细胞类胰蛋白酶(MCT)在口腔鳞癌患者血清中表达水平的研究

Studies on the Expression Level of Mast Cell Tryptase(MCT)in Serum of Squamous Cell Carcinoma

目的:通过对比检测口腔鳞癌患者、良性颌面部肿瘤患者及健康对照者血清中的肥大细胞类胰蛋白酶(MCT)的表达水平,分析其在口腔鳞癌患者血清的表达水平有无异常,并分析其潜在的临床意义。方法:收集63例口腔鳞癌患者、47例颌面良性肿瘤患者及55例健康对照者的血清,用ELISA试剂盒检测血清中MCT的表达水平,后分析口腔鳞癌患者血清中MCT水平的临床意义。结果:口腔鳞癌患者血清中的MCT的表达水平高于其它两组,但不具有显著的统计学差异(P=0.09),而在口腔鳞癌组,MCT的浓度水平与肿瘤的大小呈正性相关,此外,在中分化鳞癌中MCT的表达水平相对较高。结论:MCT作为肥大细胞聚集、活化的标记物之一,在口腔鳞癌患者血清的表达并未显著升高,而血清MCT的表达水平与肿瘤大小有关。

Objective：To detect the expression level of mast cell tryptase（MCT）in serum of oral squamous cell carcinoma,benign maxillofacial cancer and healthy controls,and analyse its potential clinical significance in patients with OSCC.Methods：The serums from 63 case of OSCC,47 cases with maxillofacial benign tumor and 55 healthy controls were collected,and the MCT in serum was detected using MCT ELISA kit.Results：The MCT expression level in serum from patient with OSCC was higher than the other two groups,but without significant difference（P=0.09）,and in cases with OSCC,MCT concentration levels was positively associated with tumor size,in addition,moderately differentiated OSCC had relatively higher expression levels of MCT.Conclusion：MCT,as an indicator of mast cell aggregation,activation,did not significantly increase in serum from OSCC patients,and the expression level of MCT was associated with tumor size.