Structures and Antiviral Activities of Butyrolactone Derivatives Isolated from Aspergillus terreus MXH-23

A new butyrolactone derivative,namely butyrolactone Ⅷ （1）,and six known butyrolactones （2-7） were separated from the ethyl acetate （EtOAc） extract of the fermentation broth of a fungus,Aspergillus terreus MXH-23.The chemical structures of these metabolites were identified by analyzing their nuclear magnetic resonance （NMR） and mass spectrometry （MS）.Known butyrolactone derivatives contain an α,β-unsaturated γ-lactone ring with α-hydroxyl and y-benzyl,and butyrolactone Ⅷ （1） was the first butyrolactones contains α-benzyl and γ-hydroxyl on α,β-unsaturated lactone ring.All of the butyrolactone derivatives were tested for their anti-influenza （H 1N 1） effects.Derivatives 4 and 7 showed moderate antiviral activities while the newly-identified,derivative 1,did not.

A new butyrolactone derivative, namely butyrolactone VIII(1), and six known butyrolactones(2-7) were separated from the ethyl acetate(Et OAc) extract of the fermentation broth of a fungus, Aspergillus terreus MXH-23. The chemical structures of these metabolites were identified by analyzing their nuclear magnetic resonance(NMR) and mass spectrometry(MS). Known butyrolactone derivatives contain an α,β-unsaturated γ-lactone ring with α-hydroxyl and γ-benzyl, and butyrolactone VIII(1) was the first butyrolactones contains α-benzyl and γ-hydroxyl on α,β-unsaturated lactone ring. All of the butyrolactone derivatives were tested for their anti-influenza(H1N1) effects. Derivatives 4 and 7 showed moderate antiviral activities while the newly-identified, derivative 1, did not.