树突细胞在慢性乙型肝炎病毒感染中的作用

Advances on the role of dendritic cells in chronic hepatitis B virus infection

大量研究表明，HBV特异的T细胞衰竭会引发病毒的持续感染。而在引发T细胞免疫的过程中DC是最重要的APC。DC通过调控启动一系列效应分子的功能，是先天性和适应性免疫系统连接的关键环节，这均有利于病原体的清除。因此，深入了解慢性HBV感染者中DC的异常状态对指导抗病毒治疗具有重要意义。此文综述了DC识别HBV抗原的3种可能方式、慢性HBV感染患者外周血DC特点、DC表面T0ll样受体9的表达异常及CD141＋DC在抗HBV免疫中的重要意义。

Previous studies have shown that HBV-specific T cell failure might cause viral persistence. DCs are the most important antigen-presenting cells for T cell stimulation. DCs form the pivotal link between the innate and the adaptive immune systems by controlling the initiation of a diverse set of effector functions, which are suitable for eliminating the pathogens. Thus, understanding the abnormal state of DCs is of great significance to guide antiviral treatment. In this article, we review three possible ways by which DCs recognize HBV, the properties of peripheral blood DCs from patients with chronic HBV infection, the abnormal expression of TLR9 and the significance of CD141＋ DCs in antiviral immunity.