克罗恩病患者口腔黏膜损害研究

The characteristics of oral mucosal in patients with Crohn's disease

目的:探讨口腔黏膜病变在克罗恩病(CD)患者中的临床特征。方法:将诊断为CD的59例患者由消化内科医师分为口腔型及非口腔型,再经口腔科医师对全部CD患者的口腔黏膜情况进行专科检查,分析CD患者中的口腔黏膜病变特征,并对两组之间的肠道病变部位进行分析研究。结果:59例CD患者中口腔型CD(23/32)比非口腔型CD(7/27)有更多的病例表现为口腔方面症状,在32例口腔型CD患者中,最常见的口腔黏膜损害为卡他性牙龈炎(n=19),其次为复发性阿弗他溃疡(n=8),肉芽肿性病变(n=4),鹅卵石样改变(n=3),唇炎(n=3),增殖性化脓性口腔炎(n=1)。口腔型CD患者合并有肛周疾病者占53%(17/32),多于非口腔型CD患者的22%(6/27)。结论:口腔症状在CD患者的临床表现中占有较大比例,其中最为常见的口腔表现为卡他性牙龈炎,有口腔症状的CD患者更有可能合并有肛周病变。

Objective：To investige the clinical features of oral mucosal in Crohn＆#39;s disease. Method：59 diagnosed as Crohn＆#39;s disease（CD） were divided into oral CD group and nonoral CD group. Oral mucosa were examinated by the dentist for the CD patients, and intestinal tract were tested by the digestive physician for the CD patients,respectively. Result：The symptoms of orla were more significant in the oral CD（23/32） group than those in the nonorla CD（7/27） group. In the o-ral CD patients group,mucogingivitis was the most common lesions of oral mucosa （N=19）,following by recurrent aphthous ulcer（N=8）,granuloma（N=4）,cobblestoning（N=3）,lip swelling（N=3）,and pyostomatitis vegetans（N=1）. In addition,peri-anal complications were more significant in the oral CD（17/32） group than those in the nonorla CD group（6/27）. Con-clusion：Oral mucosa lesions were significant symptoms in the patients with CD,and mucogingivitis was the most common le-sions of oral mucosa in the patients with oral CD. Perianal complications were more likely to be merged in the patients with oral CD.