家族性高三酰甘油血症家系心脑血管终点事件观察

Observation of cardiac and cerebral vascular endpoint events of families with familial hypertriglyceridemia

目的探讨高三酰甘油血症对心脑血管终点事件的影响及意义。方法利用家族性高三酰甘油血症2个家系10年资料,观察家系成员心脑血管终点事件的发生情况。结果家系1中Ⅲ1在研究当年因出血性脑卒中去世;Ⅲ3在研究第3年因出血性脑卒中去世;其余成员均无心脑血管终点事件发生。家系2所有成员10年随访无心脑血管终点事件发生。结论家族性高三酰甘油血症家系中单纯三酰甘油升高不会发生心脑血管终点事件;当有高血压危险因素存在时,高三酰甘油血症患者的脑血管终点事件增加。

Objective To investigate the effects of hypertriglyceridemia on cardiac and cerebral vascular endpoint events.Methods The data of familial hypertriglyceridemia in 10 years were collected and the occurrence of cardiac and cerebral vascular endpoint events of 2 family members was observed.Results In Family 1,Ⅲ1 died of hemorrhagic stroke in the first year of study and Ⅲ 3 died of hemorrhagic stroke in the third year of study.Cardiac and cerebral vascular endpoint events did not occur among the rest family members.In Family 2,no cardiac and cerebral vascular endpoint events occurred.Conclusion For familial hypertriglyceridemia,pure hypertriglyceridemia does not cause cardiac and cerebral vascular endpoint events.The occurrence of cerebrovascular endpoint events increases with the presence of hypertension.