血小板计数预测宫颈癌新辅助化疗效果的价值探讨

The Predictive Value of Neoadjuvant Chemotherapy Effect in Cervical Patients by the Platelet Counts

目的：探讨血小板计数值预测宫颈癌新辅助化疗（NACT）效果的价值。方法：收集2011年6月至2012年10月昆明医科大学第二附属医院宫颈癌患者40例,NACT 1-3个疗程,化疗结束后4周评价治疗效果。化疗前采用全自动血细胞分析仪检测宫颈癌患者血小板计数。结果：1NACT临床有效率是75%（30/40）。2宫颈癌NACT无效组患者血小板计数显著高于有效组,非鳞癌患者的血小板计数显著高于鳞癌患者（P〈0.05）。3宫颈癌患者血小板计数与NACT效果呈负相关（r=-0.218,P〈0.05）。结论：血小板计数对预测宫颈癌NACT的效果有一定临床价值。

Objective：To investigate the predictive value of neoadjuvant chemotherapy（ NACT） effect in cervical patients by the platelet counts. Methods ：40 cervical cancer patients in Yunnan Province CancerHospital from 2011.6 -2012. 10 were treated with 1-3 cycles of neoadjuvant chemotherapy and evaluated the therapeutic effects 4 weeks later after treatment completed. The platelet counts were detected by the automatic blood cell analyzer. Results：①The effective rate of NACT was 75% （30/40） ;②The platelet counts in ineffective group were significantly higher than that in effective group;The platelet counts in non-squamous carcinoma group were significantly higher than that in squamous carcinoma group（ P 〈 0. 05 ）. ③There was negative correlation between the platelet counts and NACT effect（ r = -0. 218, P = 0. 008）. Conclusions： Platelet counts can predict cervical cancer NACT effect.