超滤法测定脱氢卡维丁的血浆蛋白结合率

Plasma protein binding rate of dehydrocavidine determined by ultrafiltration

目的:测定脱氢卡维丁的血浆蛋白结合率。方法:采用超滤法和高效液相色谱法对脱氢卡维丁的血浆蛋白结合率进行测定。结果:脱氢卡维丁与牛血清白蛋白、人血浆和大鼠血浆的蛋白结合率分别为(22.91±1.40)%、(54.35±2.95)%及(52.11±2.31)%。结论:脱氢卡维丁与血浆蛋白具有较低强度的结合。

OBJECTIVE To determine the plasma protein binding rate of dehydrocavidine. METHODS Ultrafiltration combined high performance liquid chromatography was employed to determine the plasma protein binding rate of dehydrocavidine. RESULTS The plasma protein binding rates of dehydrocavidine with bovine serum albumin, human plasma and rat plasma were （22. 91 ± 1.40） %, （54. 35 ± 2. 95） % and （52. 11 ± 2. 31） %, respectively. CONCLUSION The binding rate of dehydrocavidine with plasma protein is low.