舒血宁联合脑苷肌肽治疗血管性痴呆的疗效研究

Effects of Shuxuening injection and cattle encephal on glycoside and ignotin injection in combination treatment of mental and behavior symptoms of vascular dementia

目的观察舒血宁联合脑苷肌肽治疗血管性痴呆患者的疗效及对精神行为症状的改善情况。方法将58例血管性痴呆患者随机分为舒血宁联合脑苷肌肽治疗的观察组和单纯脑苷肌肽治疗的对照组,治疗结束后观察两组患者的临床疗效、简易智能量表(MMSE)、日常生活活动能力量表(ADL)评分以及安全性评价。结果治疗后,观察组有效率为89.66%,优于对照组的72.41%,组间差异有统计学意义(P<0.05)。治疗后两组患者的MMSE、ADL评分均较治疗前明显增加,差异均有统计学意义(P<0.05);而组间比较,观察组的MMSE、ADL评分均较对照组明显增加,差异亦有统计学意义(P<0.05),且均未出现不良反应。结论舒血宁联合脑苷肌肽治疗血管性痴呆患者,不仅疗效较佳,安全性高,而且可有效改善患者的精神行为症状。

Objective To study the effects of Shuxuening injection and cattle encephal on glycoside and ignotin injection in combination treat mental and behavior symptoms of vascular dementia. Methods 58 patients were randomly divided into Shuxuening injection and cattle encephal on glycoside and ignotin injection group and cattle encephal on glycoside and ignotin injection group. The changes of clinical curative effect, MMSE, ADLseore and safety evaluation were observed. Results After treatment, the effective rate in the observation group and control group were 89.66% and 72.41%（P〈0.05）. The MMSE and ADL after treatment were significantly increased compared with those before treatment （P〈0.05）. The MMSE scores of ADL o fthe observation group were lower than those in the control group （P〈 0.05）. There was no adverse reaction. Conclusion Shuxuening and cattle encephal on glycoside and ignotin injection not only can improve the clinical curative effect in patients with vascular dementia, but also can control the mental and behavior symptoms of vascular dementia.