白花蛇舌草抗肿瘤机制研究进展及其在血液病中的应用

Research progress on anti-tumor effect and mechanisms of hedyotis diffusa willd and its application in blood disease

白花蛇舌草含有黄酮、三萜类、甾醇类等多种抗肿瘤活性成分,其主要通过诱导肿瘤细胞凋亡、产生超氧化物、影响癌基因表达、增强免疫功能、干扰肿瘤细胞能量代谢等多种途径起到抗肿瘤的作用。目前该药在抗肿瘤方面的作用已得到研究者普遍认可,但其作用机制尚未完全明确,需建立多方面实验及临床研究,以进一步阐明各成分抗肿瘤作用机制,为临床上多种肿瘤的治疗提供一种有效的药物。现笔者查阅近年来相关文献,对该药抗肿瘤机制的研究进展及其在血液病中的应用做一综述,以供实验研究及临床参考。

The studies indicate that hedyotis diffusa willd contains many kinds of anti-tumor active ingredients, such as flavonoids, triterpenoids and sterols, etc. Most of them play the anti-tumor effect through a variety of ways, mainly by inducing tumor cell apoptosis, generating superoxide, influencing cancer gene expression, enhancing immune function, interfering tumor cell energy metabolism and so on. Nowadays, the anti-tumor effect of the drug has been recognized by most researchers, but its mechanisms of anti-tumor effect are not fully clear, many experimental and clinical researches need to be established, which need further clarify anti-tumor mechanism and provide a kind of effective drug for a variety of tumors. Through analysis of the literature in recent years, it reviews the research progress on the mechanisms of anti-tumor and application in blood disease, to provide some references for experimental study and clinical application.