哮喘发作期轻中度患者风哮病例中西医治疗方案临床疗效及炎性指标疗效对比研究

Comparative study on the clinical curative effect and inflammatory indicators effect of Chinese and western medicine treatment in treating wind xiao patients in the stage of mild-to-moderate acute asthma

目的:初步评价中医辨证治疗、中医辨证治疗加穴位贴敷、西药常规治疗三者对于哮喘轻中度发作风哮患者临床疗效。方法:将157例轻中度发作期哮喘患者随机分为3组,辨证组予中药颗粒剂麻苏止哮汤,综合组在辨证组基础上加用中药穴位贴敷,西药组按照哮喘指南口服西药,治疗10d。观察患者治疗前后中医症状积分、哮喘控制指标、嗜酸性粒细胞(EOS)的比值及实测值。结果:3种治疗方法均能显著改善中医症状积分、哮喘控制指标(P<0.01),辨证组白天症状改善优于其余两组(P<0.01),且辨证组可显著降低血清EOS的比值及实测值(P<0.01,P<0.05)。结论:3种治疗方案均能有效控制哮喘轻中度中医辨证风哮患者的急性发作,其中辨证组在白天症状控制上优于西药组及综合治疗组,且能降低血清EOS的比值及实测值。

Objective： To evaluate the clinical curative effect of syndrome differentiation and treatment of TCM, syndrome differentiation and treatment of TCM combined with acupoint application and conventional western medicine treatment in treating with wind xiao patients in the stage of mild-to-moderate acute asthma preliminary. Methods： 157 patients were divided into 3 groups randomly. Patients in group A were treated with Masu Zhixiao Decoction, patients in group B were treated with acupoint application based on the treatment of Masu Zhixiao Decoction, and patients in group C were treated with western medicine according to the asthma guidelines. All the patients were treated for 10 days. The TCM symptom scores, asthma control indicators, the ratio of eosinophils （EOS） and measurement values were observed before and after treatment. Results： The TCM symptom scores, asthma amtrol indicators of the three groups was all improved significantly （P〈0.01）. The curative effect of daytime symptom in group A was better than that of the other two groups （P〈0.01）, the ratio of EOS and measurement values of group A were decreased significantly （P〈0.01, P〈0.05）. Conclusion： The three groups could control the acute asthma patients with wind xiao effectively. Syndrome differentiation and treatment group has a better effect than western medicine group and comprehensive treatment group in controlling daytime syndrome, and could reduce EOS ratio and measured values.