银杏叶提取物注射液治疗急性脑梗死的临床效果观察

Clinical Effects of the Extract of Ginkgo Biloba Injection on ACI patients

目的:研究银杏叶提取物注射液治疗急性脑梗死临床效果。方法:将130例急性脑梗死患者随机均分为治疗组及对照组。两组患者入院后均采用急性脑梗死常规治疗方案。治疗组在此基础上加用银杏叶提取物注射液。两组患者均以7 d为1个疗程,共治疗2个疗程后评价疗效。结果:在血液流变学上,治疗后治疗组患者全血高切、低切黏度,纤维蛋白原、红细胞比容及红细胞聚集指数均明显低于对照组(P<0.01);在炎症因子上,治疗组患者治疗后超敏C-反应蛋白、同型半胱氨酸及白介素-6水平均低于对照组(P<0.01);治疗后,两组患者神经功能缺损评分(NIHSS)较治疗前均有明显降低(P<0.01),而在治疗7 d及治疗14 d时治疗组患者NIHSS得分均低于对照组(P<0.05)。结论:采用银杏叶提取物注射液辅助治疗急性脑梗死具有改善血流流变学、降低血栓再发风险,提高脑组织保护效果。

Objective： To explore the clinical effects of the extract of ginkgo biloba injection on the ACI patients. Methods： The 130 ACI patients were randomly divided into treatment group and control group. Both of the two groups were taken conventional treatment of ACI, and the patients in the treatment group were added the extract of ginkgo biloba injection. 7 days for a period of treatment and the clinical effects were evaluated after two periods. Results： In the blood rheology indexes, the patients in the treatment group had lower level of whole blood reduced viscosity in high shear situation, low shear situation, fibrinogen, hematocrit value and erythro-agglutation index than the control group after the treatment（P〈0.01）;In the inflammatory factor, hs-CRP, HCY and IL-6 in the treatment group were obviously lower than those in the control group after treatment（P〈0.01）; Both of the two groups had less NIHSS scores after the treatment than the scores before（P〈0.01）, and the NIHSS scores in treatment group at the 7 d and 14d of the treatment were both less than those in the control group at the same time point（P〈0.05）. Conclusion： The extract of ginkgo biloba injection can improve blood rheology, reduce recurrence risk of thrombus, and have better clinical effects of proctecting the brain tissue.