摘要
以对甲氧基苯乙酮为原料,设计合成了11个标题化合物,其结构经IR、1HNMR和ESI-MS表征确认。初步抗肿瘤活性测试表明(MTT法),大部分目标产物对人肝癌细胞Hep G2具有一定的抗增殖活性。
Eleven Schiff bases of pyrazolederivatives containing 1,2,4-triazole were synthesized from 4-methoxyacetophenone. The structures of compounds were confirmed by IR,1HNMR and ESI-MS. Preliminary anti-tumor activity determination showed that most of the synthetic compounds exhibited anti-proliferation of human hepatoma cell lines Hep G2.
出处
《化学试剂》
CAS
北大核心
2015年第1期25-28,48,共5页
Chemical Reagents
基金
贵州省教育厅黔科合人才团队字[2012]03号
遵义医学院博士科研启动基金资助项目(F-631)
贵州省科技厅黔科合人才团队[2014]4002号
关键词
吡唑
1
2
4-三氮唑
席夫碱
抗肿瘤活性
合成
pyrazole
1
2
4-triazole
Schiff base
anti-tumor activity
synthesis