磷酸肌酸钠对老老年严重肺部感染并发心力衰竭患者NT-proBNP的影响

The effect of creatine phosphate sodium on NT-proB NP levels of very elderly patients with severe pulmonary infection and heart failure

目的观察磷酸肌酸钠对老老年严重肺部感染合并心力衰竭患者血浆N末端B型钠尿肽前体(NT-pro BNP)的影响。方法将80岁以上老老年肺部感染并发心力衰竭30例患者,随机分为观察组和对照组各15例。对照组采用常规抗感染及抗心力衰竭治疗。观察组在对照组治疗基础上加用磷酸肌酸钠治疗,观察治疗1周后NT-pro BNP的变化。结果 2组治疗1周后,NT-pro BNP水平均低于治疗前,且观察组下降幅度大于对照组,差异均有统计学意义(P<0.05或P<0.01)。结论磷酸肌酸钠能迅速降低老老年严重肺部感染并发心力衰竭的NT-pro BNP水平,改善全身状况。

Objective To observe the effect of creatine phosphate sodium on NT-proBNP levels of very elderly pa-tients with severe pulmonary infection and heart failure. Methods The 30 patients with serious pulmonary infection and heart failure were randomly divided into observation group and control group,each of 15 cases. The control group were received con-ventional treatment,and the observation group were given the Creatine phosphate sodium based on the conventional treatment. After a week of treatment,observed the BNP level changes of the two groups. Results BNP was to some extent decline in both groups（P〈0. 05）,and the observation group＇s BNP was significantly lower than the control group＇s（P〈0. 05）. Conclusion Creatine phosphate sodium can reduce BNP level in very elderly patients with severe pulmonary infection and heart failure, and improve the general condition of patients.