摘要
目的：探讨超敏 C-反应蛋白（hs-CRP）与急性脑梗死近期预后的关系。方法收集2012年4月-2013年10月连续入住河北联合大学附属医院神经内科二病区的急性脑梗死患者252例。根据血清 hs-CRP 水平采用四分位法分组，以最低分位数为参照组，采用单因素及多因素 Logistic 回归分析方法，分析血清 hs-CRP 水平变化与急性脑梗死近期预后的相关性。结果应用 Logistic 回归分析模型校正了高血压病史、冠心病史、饮酒史、并发症、NIH-SS 评分、年龄混杂影响后，与≤0.30mg/ L 组比较，≥3.41mg/ L 组 OR 值（95％ CI）为：4.22（1.09~16.615）。结论hs-CRP 水平升高是急性脑梗死预后不良的危险因素。
Objective To explore the relationship between hs-CRP and short-term prognosis in patients with acute cerebral infarction. Methods Consecutively collecting 252 acute cerebral infarction patients during April,2012 to October, 2013 in the second nerval medical department ward of Hebei United University Hospital. All the patients were divided into four groups by quartile method according to the serum hs-CRP levels,Unadjusted and multiple adjusted logistic regression models were used to analyze the relationship between hs-CRP and short-term prognosis in patients with acute cerebral infarction. Re-sults Multivariate logistic regression（ adjusted for hypertension,drinking,infarction position,complication,dyslipidemia, NIHSS score,age. ）showed that：the OR value and 95% CI was higher in hs-CRP level≥3. 41mg/ L group[4. 22（1. 09 ~16. 615）]than in hs-CRP level ≤0. 30 mg/ L group. Conclusion Elevated hs-CRP level is risk factor for early poor prognosis in patients with acute ischemic stroke.
出处
《临床合理用药杂志》
2015年第2期6-7,共2页
Chinese Journal of Clinical Rational Drug Use
