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限制性液体复苏减少失血性休克大鼠死亡率实验观察

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摘要 目的观察限制性液体复苏疗法对大鼠失血性休克死亡率的影响。方法将80只SD大鼠随机分成假手术对照组(A组)、不补液组(B组)、限制补液组(C组)和常规补液组(D组),通过颈动脉抽血制造急性失血性休克模型,同时通过剪尾制造活动性出血模型。之后分别对各组进行相应的补液方案治疗,在达到各组补液要求后停止补液并观察及统计6h内各组大鼠死亡情况。结果 A组大鼠死亡1只(5.0%);B组大鼠死亡率最高16只(80.0%);C组大鼠死亡率3只(15.0%)明显低于D组7只(35.0%)。各组间差异均有统计学意义(P<0.05)。结论限制性液体复苏在治疗性失血性休克上效果优于常规补液法。
作者 谢琴
出处 《临床合理用药杂志》 2015年第2期129-130,共2页 Chinese Journal of Clinical Rational Drug Use
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