2-氯-5-三氯甲基吡啶的合成研究

Synthesis of 2-chloro-5-trichloromethylpyridine

以3-甲基吡啶和氯气为原料,铂络合物为催化剂研究合成2-氯-5-三氯甲基吡啶。结果表明,反应优化条件为:原料氯气与3-甲基吡啶的摩尔比为8:1,催化剂用量为3-甲基吡啶质量的5%,反应温度140℃、时间8 h,在此条件产率可达79.0%。研究结果具有一定的工业化应用前景。

2-chloro-5-trichloromethylpyridine was synthesized by using 3-methylpyridine and chlorine as the starting material,platinum complex as catalyst. The optimal conditions with 79.0% yield were: molar ratio of chlorine and 3-methylpyridine was 8:l,mass fraction of catalyst and 3-methylpyridine was 0.05, the reaction temperature was 65 ℃, and reaction time was 8h.