期刊文献+

Th2和非Th2相关性支气管哮喘表型的研究进展 被引量:4

原文传递
导出
摘要 近年来越来越多的研究结果表明,支气管哮喘(简称哮喘)是一种异质性疾病,其临床表型、发病机制以及病理生理改变均复杂多样。随着对哮喘异质性的认识不断加深,人们从哮喘的不同角度进行观察并归纳出多种临床和炎症表型。哮喘表型分类繁多,本文就Th2和非Th2相关性哮喘表型进行综述。
出处 《中华结核和呼吸杂志》 CAS CSCD 北大核心 2014年第12期931-933,共3页 Chinese Journal of Tuberculosis and Respiratory Diseases
基金 浙江省自然科学基金(Y2080466)
  • 相关文献

参考文献28

  • 1Wenzel SE. Asthma: defining of the persistent adult phenotypes [ J]. Lancet ,2006,368:804-813.
  • 2Ltvall J,Akdis CA, Bacharier LB, et al. Asthma endotypes : a new approach to classification of disease entities within the asthma syndrome [ J ]. J Allergy Clin Immuno1,2011,127 :355-360.
  • 3Moore WC, Meyers DA,Wenzel SE, et al. Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program[ J]. Am J Respir Crit Care Med,2010,181:315-323.
  • 4Fitzpatrick AM, Teague WG, Meyers DA, et al. Heterogeneity of severe asthma in childhood: confirmation by cluster analysis of children in the National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program [ J ]. J Allergy Clin Immunol,2011,127 :382-389.
  • 5Moffatt MF, Gut IG, Demenais F, et al. A large-scale, consortium- based genome-wide association study of asthma [ J ]. N Engl J Med ,2010,363 : 1211-1221.
  • 6Berry M, Morgan A, Shaw DE, et al. Pathological features and inhaled corticosteroid response of eosinophilic and non-eosinophilic asthma[ J]. Thorax,2007,62:1043-1049.
  • 7Maneechotesuwan K,Yao X, Ito K, et al. Suppression of GATA-3 nuclear import and phosphory-latian: a novel mechanism of corticosteroid action in allergic disease [ J ]. PLoS Med, 2009,6 : e1000076.
  • 8Wenzel S, Wilbraham D, Fuller R, et al. Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studies [ J]. Lancet, 2007,370 : 1422-1431.
  • 9Jayaram L, Pizzichini MM, Cook R J, et al. Determining asthma treatment by monitoring sputum cell counts : effect on exacerbations [ J]. Eur Respir J ,2006,27:483-494.
  • 10Woodruff PG, Modrek B, Choy DF, et al. T-helper type 2-driven inflammation defines major subphenotypes of asthma [ J ]. AmJ Respir Crit Care Med,2009 ,180 :388-395.

二级参考文献8

  • 1McFadden ER Jr, Gilbert IA. Exercise-induced asthma. N Engl J Med, 1994,330 : 1362-1367.
  • 2Reiss TF, Hill JB, Harman E, et al, Increased urinary excretion of LTE4 after exercise and attenuation of exercise-induced bronchospasm by montelukast, a cysteinyl leukotriene receptor antagonist. Thorax, 1997,52 : 1030-1035.
  • 3vBronsky EA, Kemp JP, Zhang J, et al. Dose-related protection of exercise bronchoconstriction by montelukast, a cysteinyl leukotrienereceptor antagonist,at the end of a once-daily dosing interval. Clin Pharmacol Ther, 1997,62:556-561.
  • 4Crapo RO, Casaburi R,Coates AL,et al. Guidelines for methacholine and exercise challenge testing-1999. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors,July 1999. Am J Respir Crit Care Med,2000,161:309-329.
  • 5Reiss TF, Chervinsky P, Dockhorn R J, et al. Montelukast, a oncedaily leukotriene receptor antagonist, in the treatment of chronic asthma: a muhicenter, randomized, double-blind trial. Montelukast Clinical Research Study Group. Arch Intern Med, 1998,158 : 1213-1220.
  • 6Leff JA,Busse WW, Pearlman D, et al. Montelukast, a leukotrienereceptor antagonist, for the treatment of mild asthma and exerciseinduced bronchoconstriction. N Engl J Med, 1998,339 : 147-152.
  • 7支气管哮喘防治指南[J].中华结核和呼吸杂志,1997,20(5):261-267. 被引量:2006
  • 8孙铁英,郭岩斐,张洪胜.白三烯在运动性哮喘中作用的初步探讨[J].中华医学杂志,2002,82(1):54-56. 被引量:12

共引文献4

同被引文献40

  • 1Ling H,Fabbri M,Calin GA.MicroRNAs and other non - coding RNAs as targets for anticancer drug development [J].Nat Rev Drug Discov,2013,1201):847-865.
  • 2Das J,Podder S,Ghosh TC.Insights into the miRNA regulations in human disease genes[J].BMC Genomics,2014,15:1010.
  • 3Salmena L,Poliseno L,Tay Y,et al.A ceRNA hypothesis:the Rosetta Stone of a hidden RNA language?[J].Cell,2011,146(3):353-358.
  • 4Martinez - Nunez RT,Bondanese VP,Louafi F,et al.A microR- NA network dysregulated in asthma controls IL -6 production in bronchial epithelial cells [J].PLoS One,2014,9(10):elll659.
  • 5Haj - Salem I,Fakhfakh R,Berube JC,et al.MicroRNA -19a en- hances proliferation of bronchial epithelial cells by targeting TGFbe- taR2 gene in severe asthma[J].Allergy,2015,70(2):212-219.
  • 6Bleck B,Grunig G,Chiu A,et al.MicroRNA -375 regulation of thymic stromal lymphopoietin by diesel exhaust particles and ambi- ent particulate matter in human bronchial epithelial cells [J].J Immunol,2013,190(7):3757-3763.
  • 7Comer BS,Camoretti - Mercado B,Kogut PC,et al.MicroRNA -146a and microRNA -146b expression and anti - inflammatory function in human airway smooth muscle[J].Am J Physiol Lung Cell Mol Physiol,2014,307(9):L727-L734.
  • 8Hu R,Pan W,Fedulov AV,et al.MicroRNA - 10a controls air- way smooth muscle cell proliferation via direct targeting of the PI3 kinase pathway[J].Faseb J,2014,28(5):2347-2357.
  • 9Chiba Y,Misawa M.MicroRNAs and their therapeutic potential for human diseases:MiR -133a and bronchial smooth muscle hy- perresponsiveness in asthma [J].J Pharmacol Sci,2010,114(3):264-268.
  • 10Simpson LJ,Patel S,Bhakta NR,et al.A microRNA upregulated in asthma airway T cells promotes TH2 cytokine production [J].Nat Immunol,2014,15(12):1162-1170.

引证文献4

二级引证文献53

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部