Th2和非Th2相关性支气管哮喘表型的研究进展
被引量:4
摘要
近年来越来越多的研究结果表明,支气管哮喘(简称哮喘)是一种异质性疾病,其临床表型、发病机制以及病理生理改变均复杂多样。随着对哮喘异质性的认识不断加深,人们从哮喘的不同角度进行观察并归纳出多种临床和炎症表型。哮喘表型分类繁多,本文就Th2和非Th2相关性哮喘表型进行综述。
出处
《中华结核和呼吸杂志》
CAS
CSCD
北大核心
2014年第12期931-933,共3页
Chinese Journal of Tuberculosis and Respiratory Diseases
基金
浙江省自然科学基金(Y2080466)
参考文献28
-
1Wenzel SE. Asthma: defining of the persistent adult phenotypes [ J]. Lancet ,2006,368:804-813.
-
2Ltvall J,Akdis CA, Bacharier LB, et al. Asthma endotypes : a new approach to classification of disease entities within the asthma syndrome [ J ]. J Allergy Clin Immuno1,2011,127 :355-360.
-
3Moore WC, Meyers DA,Wenzel SE, et al. Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program[ J]. Am J Respir Crit Care Med,2010,181:315-323.
-
4Fitzpatrick AM, Teague WG, Meyers DA, et al. Heterogeneity of severe asthma in childhood: confirmation by cluster analysis of children in the National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program [ J ]. J Allergy Clin Immunol,2011,127 :382-389.
-
5Moffatt MF, Gut IG, Demenais F, et al. A large-scale, consortium- based genome-wide association study of asthma [ J ]. N Engl J Med ,2010,363 : 1211-1221.
-
6Berry M, Morgan A, Shaw DE, et al. Pathological features and inhaled corticosteroid response of eosinophilic and non-eosinophilic asthma[ J]. Thorax,2007,62:1043-1049.
-
7Maneechotesuwan K,Yao X, Ito K, et al. Suppression of GATA-3 nuclear import and phosphory-latian: a novel mechanism of corticosteroid action in allergic disease [ J ]. PLoS Med, 2009,6 : e1000076.
-
8Wenzel S, Wilbraham D, Fuller R, et al. Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studies [ J]. Lancet, 2007,370 : 1422-1431.
-
9Jayaram L, Pizzichini MM, Cook R J, et al. Determining asthma treatment by monitoring sputum cell counts : effect on exacerbations [ J]. Eur Respir J ,2006,27:483-494.
-
10Woodruff PG, Modrek B, Choy DF, et al. T-helper type 2-driven inflammation defines major subphenotypes of asthma [ J ]. AmJ Respir Crit Care Med,2009 ,180 :388-395.
二级参考文献8
-
1McFadden ER Jr, Gilbert IA. Exercise-induced asthma. N Engl J Med, 1994,330 : 1362-1367.
-
2Reiss TF, Hill JB, Harman E, et al, Increased urinary excretion of LTE4 after exercise and attenuation of exercise-induced bronchospasm by montelukast, a cysteinyl leukotriene receptor antagonist. Thorax, 1997,52 : 1030-1035.
-
3vBronsky EA, Kemp JP, Zhang J, et al. Dose-related protection of exercise bronchoconstriction by montelukast, a cysteinyl leukotrienereceptor antagonist,at the end of a once-daily dosing interval. Clin Pharmacol Ther, 1997,62:556-561.
-
4Crapo RO, Casaburi R,Coates AL,et al. Guidelines for methacholine and exercise challenge testing-1999. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors,July 1999. Am J Respir Crit Care Med,2000,161:309-329.
-
5Reiss TF, Chervinsky P, Dockhorn R J, et al. Montelukast, a oncedaily leukotriene receptor antagonist, in the treatment of chronic asthma: a muhicenter, randomized, double-blind trial. Montelukast Clinical Research Study Group. Arch Intern Med, 1998,158 : 1213-1220.
-
6Leff JA,Busse WW, Pearlman D, et al. Montelukast, a leukotrienereceptor antagonist, for the treatment of mild asthma and exerciseinduced bronchoconstriction. N Engl J Med, 1998,339 : 147-152.
-
7支气管哮喘防治指南[J].中华结核和呼吸杂志,1997,20(5):261-267. 被引量:2006
-
8孙铁英,郭岩斐,张洪胜.白三烯在运动性哮喘中作用的初步探讨[J].中华医学杂志,2002,82(1):54-56. 被引量:12
共引文献4
-
1孙铁英.现代支气管哮喘治疗面临的挑战和机遇[J].中华结核和呼吸杂志,2005,28(12):813-815. 被引量:3
-
2徐圣葆,梅晓冬.白三烯受体拮抗剂研究新进展[J].安徽医药,2007,11(12):1057-1059. 被引量:9
-
3孙铁英.运动试验的临床应用[J].中国康复理论与实践,2009,15(5):408-409. 被引量:2
-
4杨莉颖,陈慧,杨红丽.孟鲁司特钠对多种儿童哮喘的临床应用进展研究[J].吉林医学,2016,37(12):3018-3020. 被引量:2
同被引文献40
-
1Ling H,Fabbri M,Calin GA.MicroRNAs and other non - coding RNAs as targets for anticancer drug development [J].Nat Rev Drug Discov,2013,1201):847-865.
-
2Das J,Podder S,Ghosh TC.Insights into the miRNA regulations in human disease genes[J].BMC Genomics,2014,15:1010.
-
3Salmena L,Poliseno L,Tay Y,et al.A ceRNA hypothesis:the Rosetta Stone of a hidden RNA language?[J].Cell,2011,146(3):353-358.
-
4Martinez - Nunez RT,Bondanese VP,Louafi F,et al.A microR- NA network dysregulated in asthma controls IL -6 production in bronchial epithelial cells [J].PLoS One,2014,9(10):elll659.
-
5Haj - Salem I,Fakhfakh R,Berube JC,et al.MicroRNA -19a en- hances proliferation of bronchial epithelial cells by targeting TGFbe- taR2 gene in severe asthma[J].Allergy,2015,70(2):212-219.
-
6Bleck B,Grunig G,Chiu A,et al.MicroRNA -375 regulation of thymic stromal lymphopoietin by diesel exhaust particles and ambi- ent particulate matter in human bronchial epithelial cells [J].J Immunol,2013,190(7):3757-3763.
-
7Comer BS,Camoretti - Mercado B,Kogut PC,et al.MicroRNA -146a and microRNA -146b expression and anti - inflammatory function in human airway smooth muscle[J].Am J Physiol Lung Cell Mol Physiol,2014,307(9):L727-L734.
-
8Hu R,Pan W,Fedulov AV,et al.MicroRNA - 10a controls air- way smooth muscle cell proliferation via direct targeting of the PI3 kinase pathway[J].Faseb J,2014,28(5):2347-2357.
-
9Chiba Y,Misawa M.MicroRNAs and their therapeutic potential for human diseases:MiR -133a and bronchial smooth muscle hy- perresponsiveness in asthma [J].J Pharmacol Sci,2010,114(3):264-268.
-
10Simpson LJ,Patel S,Bhakta NR,et al.A microRNA upregulated in asthma airway T cells promotes TH2 cytokine production [J].Nat Immunol,2014,15(12):1162-1170.
引证文献4
-
1何旗,王凌伟,邱晨.microRNA与支气管哮喘的研究进展[J].广东医学,2016,37(14):2196-2199. 被引量:15
-
2张惠民,李建英,任志超.支气管哮喘急性发作期血氧饱和度水平与磷脂酶Cε的关系[J].内科急危重症杂志,2018,24(1):19-21. 被引量:3
-
3赵晨曲,杜娟,董亚琼.支气管哮喘的诊治进展[J].贵州医药,2018,42(9):1060-1062. 被引量:31
-
4陈润南,朱蕾.罗氟司特治疗支气管哮喘的研究进展[J].中华结核和呼吸杂志,2020,43(8):698-701. 被引量:4
二级引证文献53
-
1何宗林,邓嘉,梁爱玲,向大开,唐静,颜田赅.维生素D联合布地奈德福莫特罗对支气管哮喘患者临床疗效及PEF变异率的影响[J].慢性病学杂志,2021,21(6):975-977.
-
2马晶晶,马佳玲.个案护理管理模式对老年哮喘患者自护能力及服药依从性影响[J].社区医学杂志,2020,0(5):360-362.
-
3雷盛钦,胡水婷,程丽,黄小燕.低剂量脂多糖对哮喘小鼠T淋巴细胞产生IL-17的影响[J].中国当代医药,2017,24(3):120-122.
-
4雷琳,陈培芬,李国保.成人哮喘患者外周血单个核细胞microRNA-221表达及意义[J].中国医学工程,2017,25(3):90-92.
-
5李佳桐,张宝慧,常莉.MicroRNA与支气管哮喘的研究进展[J].解剖科学进展,2017,23(4):427-429. 被引量:2
-
6王艳春,于呈伟,齐颖会,刘振来.纤维支气管镜检标本微小RNA-21在非小细胞肺癌诊断中的临床应用价值[J].癌症进展,2018,16(2):189-191. 被引量:3
-
7贺琳娟,刘姬艳.microRNAs:支气管哮喘的潜在新靶点[J].中国医药生物技术,2018,13(4):349-352.
-
8赵茉莉,王明媛,英军,骆红山.孟鲁司特钠联合布地奈德治疗成人急性发作期支气管哮喘的效果及安全性[J].中国实用乡村医生杂志,2019,26(6):61-63. 被引量:3
-
9郭青,胡博,孙晓敏,宋春兰.孟鲁司特对哮喘小鼠气道炎症及白细胞介素-13和-5的影响[J].中华实用诊断与治疗杂志,2019,33(6):531-535. 被引量:5
-
10周碧.对支气管哮喘患者进行延续性护理对其哮喘症状及生活质量的影响[J].当代医药论丛,2019,17(11):268-270. 被引量:1
-
1朱敏,代华平,薛熠,杨汀,李颖,王辰.变应性肉芽肿性血管炎相关性哮喘二例[J].中华结核和呼吸杂志,2007,30(8):627-628. 被引量:5
-
2韩国敬,胡红.重症哮喘表型及内型的研究进展[J].中华老年多器官疾病杂志,2017,16(3):169-172. 被引量:4
-
3王菊花.红霉素治疗胃食管反流相关性哮喘疗效观察[J].山东医药,2005,45(28):66-67.
-
4王帝,郭雪君.支气管哮喘表型分类的研究进展[J].国际呼吸杂志,2014,34(23):1807-1811. 被引量:2
-
5杨玉成.胃食管反流性支气管哮喘的临床治疗观察[J].华夏医学,2006,19(2):312-312.
-
6王长征.支气管哮喘表型[J].内科理论与实践,2011,6(2):102-105. 被引量:8
-
7赵正宇,李向晖,孙军浩,夏秋萍.联合抗反流药物治疗胃-食管反流相关性哮喘32例临床分析[J].中国乡村医药,2011,18(12):10-10.
-
8张孔,周燕斌,容中生.胃、食管反流与支气管哮喘(附13例临床分析)[J].新医学,1995,26(8):414-415. 被引量:2
-
9王健,肖明英.红霉素联合雷尼替丁治疗胃食道返流相关性哮喘分析[J].云南医药,1998,19(1):28-28. 被引量:2
-
10李运泉,孔海鸿,李民华.吗丁啉治疗胃食管反流相关性支气管哮喘疗效观察[J].中国临床药理学与治疗学,2002,7(3):252-254. 被引量:2