阿奇霉素治疗儿童支原体肺炎25例疗效分析

Efficacy of azithromycin in the treatment of mycoplasmal pneumonia:a report of 25 cases

目的:探讨阿奇霉素治疗儿童支原体肺炎的疗效。方法:将支原体肺炎患儿50例随机分为2组。对照组25例,给予红霉素30 mg/kg,每天1次,连续5 d,停药2 d为1个疗程。观察组25例,给予阿奇霉素10 mg/kg,每天1次,连续5 d,停药2 d为1个疗程。比较2组患儿的疗效和肺通气功能变化。结果:观察组患儿的总有效率96.0%,高于对照组的76.0%(P<0.05);观察组患儿咳嗽消失时间、罗音消失时间和住院时间均明显短于对照组(P<0.01);2个疗程后观察组的用力肺活量和用力1 s肺活量均明显高于对照组(P<0.01);观察组胃肠道反应少于对照组(P<0.05)。结论:阿奇霉素治疗儿童支原体肺炎的疗效确切,可缩短临床症状、体征的缓解时间以及疗程和住院时间,减少不良反应,有效改善肺功能。

Objective：To investigate the clinical efficacy of azithromycin in the treatment of mycoplasmal pneumonia. Methods：Fifty children with mycoplasmal pneumonia were randomly divided into two groups. The 25 cases in the control group received the therapy of erythromycin 30 mg /kg,1 time /day,continuously for 5 days and a 2-day withdrawal as one course,and the 25 cases in the observation group azithromycin 10 mg /kg,1 time /day,continuously for 5 days and a 2-day withdrawal as one course. The clinical efficacy and changes of pulmonary ventilation function were compared between the two groups. Results：The total response rate of the observation group was 96. 0%,which was higher than that of the control（76. 0%）（P〈0. 05）. The time of cough disappearing,rales disappearing and hospital stay of the observation group was shorter than that of the control group（ P〈0. 01）;the Forced vital capacity and Forced expiratory volume in 1 second of the observation group were higher than those of the control group after 2 months＇ treatment（ P〈0.01）;the gastrointestinal reaction of the observation group was less than that of the control group（P〈0. 05）. Conclusions：The clinical efficacy of azithromycin is confirmed for treatment of mycoplasmal pneumonia. It may shorten the duration of the clinical symptoms and signs,decrease the treatment time and hospital stay,reduce the adverse reaction and improve the lung function.