摘要
目的探讨抗癌抑瘤方（太子参,白术,茯苓,厚朴,白头翁等）联合Cape Ox方案（卡培他滨联合奥沙利铂）治疗晚期结直肠癌的协同增效作用。方法入选97例晚期结直肠癌患者随机方法分为对照组（48例）和研究组（49例）,两组接受Cape Ox化疗,后者加服抗癌抑瘤方。结果研究组49例晚期结直肠癌患者中完全缓解7例,部分缓解23例,总有效率61.2%;对照组48例患者中完全缓解3例,部分缓解15例,总有效率37.5%;两组差异有显著性（P〈0.05）。研究组和对照组患者中位疾病无进展生存时间分别为11.2个月（95%CI：8.9~13.5个月）、8.9个月（95%CI：8.3~9.5个月）,两组差异显著（P〈0.05）。治疗后研究组患者在生活质量评分、疼痛评分、部分不良反应及血清癌胚抗原、糖链抗原199、基质金属蛋白酶-7、基质金属蛋白酶组织抑制因子-2水平变化等方面占有优势,与对照组对比差异较显著（P〈0.05）。结论抗癌抑瘤方对Cape Ox方案治疗晚期结直肠癌具有协同增效作用,能够延长患者生存时间,改善患者生活质量,减轻部分不良反应。
AIM To explore the synergistic effect and mechanism between the anti-tumor agent（ Pseudostellariae Radix,Atractylodis macrocephalae Rhizoma,Poria,Magnoliae officinalis Cortex,Pulsatillae Radix,etc.） and Cape Ox chemotherapy（ capecitabine plus oxaliplatin） in the treatment of advanced colorectal cancer. METHODS Ninty-seven patients with advanced colorectal cancer were randomly divided into control group（ n = 48） and trial group（ n = 49）. Patients of both groups were given Cape Ox therapy,but an anti-tumor agent was administered to the trial group. RESULTS In trial group（ n = 49）,the complete response number was 7 cases,the partial response number was 23 cases,the total effective rate was 61. 2%. In control group（ n = 48）,the complete response number was 3 cases,the parital response number was 15 cases,the total effective rate was 37. 5%,difference of two groups was prominet（ P 〈 0. 05）. The median PFS for the trial group and the control group were 11. 2 months（ 95% CI：8. 9-13. 5 months） and 8. 9 months（ 95% CI： 8. 3-9. 5 months）,respectively. After treatment,the advantages were found in the trial group in FACT,NRS,adverse events avoidance,and its levels of CEA,CA199,MMP-7,TIMP-2 were much lower,and statistical significance was observed（ P 〈 0. 05）. CONCLUSION The anti-tumor agent combined with Cape Ox chemotherapy can prolong the survival time,improve the quality of life and offset some adverse reactions,thus manage the advanced colorectal cancer effectively.
出处
《中成药》
CAS
CSCD
北大核心
2015年第1期49-54,共6页
Chinese Traditional Patent Medicine
