葡萄糖酸溶液中三组分一锅法合成新型β-吲哚衍生物

One-Pot Three-Component Synthesis of New β-Indole Derivatives in Gluconic Acid Aqueous Solution

在生物质葡萄糖酸水溶液中,醛、吲哚和2,2-亚戊基-1,3-二噁烷-4,6-二酮通过“一锅煮”三组分反应合成了13种新型β-吲哚衍生物,产率为66.4%～98.5%.该方法具有反应条件温和、底物普适性好、收率高及对环境友好等优点,为β-取代吲哚类化合物的合成提供了一种有效的新方法.

One-pot three-component reactions of aldehydes with indole and 2,2-pentamethylene-1,3-dioxane-4,6-dione af-forded thirteen kinds of 5-[（indol-3-yl）-methyl]-2,2-pentamethylene-1,3-dioxane-4,6-dione derivatives （β-indole derivatives） in the presence of gluconic acid aqueous solution in 66.4%~98.5%yields. The advantages of this protocol were mild reaction conditions, wide substrate scope, high yields and benign to environment, which afforded an effective method to synthesizeβ-indole derivatives.