CysC对2型糖尿病慢性并发症的相关性分析

Analysis of the Correlation between Serum Cystatin C and Chronic Complications of Type 2 Diabetes

目的:探讨血清胱抑素C与2型糖尿病(T2DM)慢性并发症的相关性。方法:100例T2DM患者根据是否合并T2DM慢性并发症分为无合并糖尿病并发症的糖尿病对照组(NC组),合并周围血管病变(PAD)组、合并肾脏病变(DN)组、合并视网膜病变(DR)组,合并周围神经病变(DPN)组,测定空腹血糖(FBG)、糖化血红蛋白(Hb A1c)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、空腹胰岛素(FINS)、血清胱抑素C并分析血清胱抑素C与各指标的相关性。结果:2型糖尿病合并PAD、DN、DR以及DPN组的血清CysC水平均高于不合并糖尿病并发症的糖尿病对照组(NC组)(P<0.05)。结论:血清胱抑素C升高可作为提示糖尿病周围血管病变、肾脏病变、视网膜病变、周围周围神经病变危险性增加的参考指标,并可能是T2DM患者慢性并发症的独立危险因素。

Objective： To study the correlation between Cystatin C（CysC） and chronic complications of type 2 diabetes（T2DM）. Method： 100 patients with T2DM were divided into control group without chronic complications（NC group）, PAD group with peripheral arterial diseases, DN group with diabetic nephropathy, DR group with diabetic retinopathy, and DPN group with peripheral neuropathy. Measurements were carried out for the levels of fasting blood-glucose（FBG）, glycosylated hemoglobin（Hb A1c）,total cholesterol（TC）, triglyceride（TG）, high density lipoprotein cholesterol（HDL-C）,low density lipoprotein cholesterol（LDL-C）,fasting insulin（FINS） and CysC. The correlation between CysC and other indicators were determined. Result： The serum CysC levels of T2DM patients in PAD, DN, DR and DPN group were all higher than that of the control group（NC group）（P0.05）. Conclusion： The serum CysC level can be a reference index for the higher risks of peripheral arterial diseases, diabetic nephropathy, diabetic nephropathy and peripheral neuropathy, it can also be a independent risk factor for chronic complications of type 2 diabetes patients.