地塞米松冲击疗法治疗成人原发免疫性血小板减少症的疗效观察

The Efficacy Observation of Dexamethasone Impact Therapy in the Treatment of Immune Thrombocytopenic Purpura

目的:观察地塞米松冲击疗法治疗成人原发免疫性血小板减少症(ITP)的临床疗效。方法:自2006年7月-2013年9月间笔者所在医院收治成人ITP患者38例,患者均给予胸腺肽α1联合大剂量维生素C治疗,其中19例同时应用4 d地塞米松冲击治疗,观察临床症状、血小板计数和不良反应。结果:胸腺肽α1+大剂量维生素C治疗组总有效率78.9%,平均起效时间(16.8±3.2)d;胸腺肽α1+大剂量维生素C联合地塞米松冲击治疗组总有效率84.2%,平均起效时间(6.7±2.7)d。两种治疗方案的不良反应均较轻微。结论:胸腺肽α1联合大剂量维生素C与冲击量地塞米松联合应用治疗成人ITP疗效较好,副作用少,可缩短起效时间。

Objective：To observe the curative effect of Dexamethasone impact therapy to the immune thrombocytopenic purpura（ITP）.Method：38 ITP patients were all given thymosin alpha 1（Tα1） combined highdose vitamin C,among them 19 patients were companied with flushing dose dexamethasone during the first 4 medicative days.The clinic syndrome,platelet counts and side effects were observed.Result：The total effective rate in Tα1 combined high-dose vitamin C therapy group reached 78.9%,the average onset time were（16.8±3.2）d;the total effective rate in Tα1 combined high-dose vitamin C and flushing dose dexamethasone therapy group was 84.2%, the average onset time were（6.7±2.7）d.The side effects of the two groups were slight.Conclusion：Tα1 combined highdose vitamin C and flushing dose dexamethasone has good curative effect and fewer side effects on adult ITP; it can also act fsatly.