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干细胞Nanog蛋白在食管癌组织中的表达及意义 被引量:2

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摘要 目的:通过分析干细胞Nanog蛋白在食管癌组织中的表达,进一步探讨其和食管癌病理特征存在的关系。方法:回顾性分析2012年1月-2014年1月在本院接受治疗的70例食管癌患者,收集其临床资料、癌组织及癌周围正常组织的标本等资料,采用免疫组化法检测其癌组织和癌组织周围正常细胞的干细胞Nanog蛋白,并用免疫荧光技术检测食管癌细胞系Eca-109及TE-1的Nanog蛋白表达。结果:经检测,食管癌组织中的Nanog蛋白表达水平显著高于癌周围正常组织,差异有统计学意义(P<0.05),且食管癌组织中的Nanog蛋白表达水平和食管癌病理分期、分化程度及淋巴结转移有明显关系(P<0.05)。结论:干细胞Nanog蛋白在食管癌组织中的表达水平,和食管癌病变的发生、发展及转移情况有密切关系。
出处 《中国医学创新》 CAS 2014年第36期41-42,共2页 Medical Innovation of China
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