44例阿尔茨海默病患者认知功能与脑电图特点分析

Cognitive function and electroencephalogram characteristics analysis of 44 patients with Alzheimer disease

目的对44例阿尔茨海默病（AD）患者的认知功能及其脑电图（EEG）改变进行回顾性分析,并探讨两者之间的关系。方法自2013年10月~2014年10月间,就诊于吉林大学第一医院认知障碍门诊的44例诊断为阿尔茨海默病的患者,对其临床资料、临床痴呆评定量表（CDR）、简易精神状态量表（MMSE）、蒙特利尔认知评价量表（Mo CA）、日常生活活动能力量表（ADL）及4 h录像脑电图监测结果进行回顾性分析研究。结果 EEG异常率84.1%,表现为背景节律减慢,单侧或双侧颞区出现不同程度尖波、尖慢波、棘波和棘慢波发放,以右侧颞区为主。AD患者EEG异常程度与病程及认知功能减退程度相平行。结论 EEG可作为反映AD患者认知功能较为可靠的客观指标,对掌握病情进展和判断预后有着重要作用。

Objective Restrospectively analysis the changes of the cognitive function and electroencephalogram （EEG） in 44 Alzheimer disease patients and to explore the relationship between both of them. Methods Restrospectively analysis the clinical data, Clinical Dementia Rating （CDR） 、 Mini-Mental State Examination （ MMSE ）, Montreal Cognitive Assessment（MoCA） ,Activities of Daily Living（ADL） and 4 h video-EEG results of 44 patients diagnosed as Alzheimer disease,from October 2013 to October 2014,who visited the Congnitive Impairment Department of the first hospital of Jilin University. Results The abnormal rate of EEG was 84.1% , characterized by slow background rhythm, different degree of sharp wave, sharp and wave complex, spike wave, spike and wave complex appeared in unilateral or bilateral temporal region, mainly on the right side of the temporal region. The degree of EEG abnormality within AD patients was parallel with the duration of disease and the degree of the declining of cognitive function of the patients. Conclusion EEG can be regarded as a reliable and objective indicator to reflect the cognitive function in AD patients, which is significant to know the progression of the disease and to judge its prognosis.