小脑^(18)F-氟代脱氧葡萄糖代谢正常值的研究

The study on normal value of ^(18)F-fluorodeoxyglucose (^(18)F-FDG) metabolism in cerebellum

目的观察小脑18F-氟代脱氧葡萄糖(18F-FDG)代谢水平,获得小脑葡萄糖代谢正常值范围。方法回顾性分析我院2012年8月~2014年5月期间,患有非脑血管疾病、动脉硬化风险较低的74例年轻患者的脑PET扫描图像,以小脑各感兴趣区(左右小脑皮质、蚓部、左右绒球)和大脑尾状核的标准化摄取值(standardized uptake value,SUV)的比值作为小脑葡萄糖代谢水平的相对定量参数,采用统计学方法计算正常值范围。结果以各组数据的95%可信区间为正常值范围,得到小脑半球皮质与尾状核比值的正常下限为0.40,蚓部与尾状核比值的正常下限为0.56,绒球与尾状核比值的正常下限为0.33。结论通过对正常脑的葡萄糖代谢研究,获得了小脑与大脑尾状核葡萄糖代谢比值的正常范围,为将来的后循环缺血研究奠定了基础。

Objective To establish the normal range of glucose metabolism values at cerebellar. Methods Retrospective analysis of brain PET images of 74 young patients in our hospital, who were without cerebral vascular disease and with lower risk of atherosclerosis, whose images were scanned from August,2012 to May,2014. The ratios of standardized uptake value （SUV） at regions of interest（ROI） of cerebellar cortex, vermis, flocculus to brain caudate nucleus were set as relative quantity factor. Finally, using statistical analysis calculated the normal value range. Results According to the 95 % confidence interval of the above ratios,the lower limit of the cortex/caudate nucleus ratio was 0.40, the lower limit of the vermis/caudate nuclear was 0.56 and the lover limit of the flocculus/eaudate was 0.33. Conclusion Through the study of glucose metabolism in normal brain, the normal glucose metabolic ratio of cerebellum/cerebrum caudate was obtained, thus, laid the foundation for further study on posterior circulation ischemia.