摘要
胰腺癌是消化系统恶性程度较高的肿瘤之一,如何早期发现、诊断及提高疗效是目前临床迫切需要解决的问题.近年来竞争性内源RNA假说的提出为阐明包括胰腺癌在内的多种肿瘤的发生发展机制提供了重要线索及新的研究方向.微小RNAs （miRNAs）和长链非编码RNAs （lncRNAs）均为竞争性内源RNA假说的重要组成部分,研究发现,miRNAs的过度表达和沉默,以及部分lncRNAs的异常表达均与胰腺癌的发生发展有密切关系.本文分别从竞争性内源RNA假说的内容及机制,竞争性内源RNA成员在胰腺癌等肿瘤中的作用作系统综述.
Pancreatic cancer is one of the most common gastrointestinal malignancies,and the main unsolved obstacles,which we must figure out,are the early detection and diagnosis,and the improvement in treatments.The ceRNA （competing endogenous RNA,ceRNA） hypothesis provides significant clues and a novel direction for understanding the mechanisms of tumor occurrence and progression,microRNAs and lncRNAs （long non coding RNAs,lncRNAs） are important components in ceRNA hypothesis.Researches have discovered that both overexpression and silence of miRNAs and abnormal expression of some lncRNAs are related to the occurrence and progression of pancreatic cancer.This paper reviewed the contents and mechanisms of ceRNA hypothesis,members of ceRNA network as well as the role of ceRNAs in pancreatic neoplasms.
出处
《国际外科学杂志》
2014年第12期841-844,共4页
International Journal of Surgery
基金
基金项目：国家重点基础研究发展计划（No.2014CB542300）
国家自然科学基金（No.81272484）
