帕罗西汀治疗脑卒中后抑郁障碍的临床疗效

Clinical effects of paroxetine on treating the depression of patient with post-stroke

目的探讨脑卒中后抑郁障碍患者接受帕罗西汀治疗的临床效果。方法脑卒中后抑郁障碍患者126例随机分为治疗组和对照组各63例,对照组给予脑卒中常规药物治疗,治疗组在对照组的基础上给予帕罗西汀治疗。比较2组治疗前、治疗2周、4周、8周后的汉密尔顿抑郁量表(HAMD)评分,以及治疗前后日常生活能力Barthel指数(BI)评分、神经功能缺损(SSS)评分。结果 2组治疗8周后BI评分均增加,SSS评分均减少(P<0.05),治疗组较对照组的变化更显著(P<0.05)。治疗组治疗4周、8周后HAMD评分均较治疗前降低(P<0.05),与对照组相比,差异有统计学意义(P<0.05)。结论帕罗西汀治疗脑卒中后抑郁障碍患者疗效确切,值得临床推广。

Objective To investigate the clinical effects of paroxetine on treating the depression of patient with poststroke.Methods 126 patients with post-stroke depression From April 2012 to April 2013 in our hospital were randomly divided into control group（n=63,treated with conventional medicine）and observation group（n=63,treated with conventional medicine plus paroxetine）.The Hamilton Depression Scale（HAMD）,neurologic deficit score（SSS）and daily living Barthel Index（BI）score of two groups were compared before treatment,2weeks,4weeks and 8weeks after treatment.Results Compared with the control group,there were higher BI scores,lower SSS and HAMD scores in observation group 4weeks and 8weeks after treatment,which was significant differences（P〈0.05）.Conclusion Paroxetine has certain curative effect on treating patients with post-stroke depression,which is worthy of clinical application.