期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

血浆同型半胱氨酸与不同类型脑小血管病相关性分析 被引量：8

下载PDF
导出
摘要 目的分析血同型半胱氨酸(Hcy)与不同类型脑小血管病的相关性。方法纳入脑小血管病患者123例(病例组),其中单纯脑白质疏松症(LA)39例,腔隙性梗死(LI)35例,脑微出血(CMB)16例,脑白质疏松并腔隙性梗死和(或)脑微出血33例,40例健康者为对照组。对2组患者均进行Hcy检测。结果 LA、LI、CMB及脑白质疏松并腔隙性梗死和(或)脑微出血组血浆同型半胱氨酸均高于对照组(P<0.05),脑白质疏松并腔隙性梗死和(或)脑微出血组血浆同型半胱氨酸明显高于其他3组脑小血管病组(P<0.05),LA、LI及CMB血浆同型半胱氨酸无明显差异。结论 Hcy与脑小血管病(SVB)的病情严重程度具有密切关系。
作者 王立侠 董俊兴 焦敬美
机构地区 郑州市第七人民医院
出处 《中国实用神经疾病杂志》 2014年第24期75-76,共2页 Chinese Journal of Practical Nervous Diseases
关键词 脑小血管病 血浆同型半胱氨酸 脑微出血 脑白质疏松症 腔隙性梗死
分类号 R743 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献10

  • 1李伟,李桂林,王拥军.脑小血管病[J].中华内科杂志,2010,49(2):163-164. 被引量：40
  • 2Yamauchi H,Fukuda H, Oyanagi C. Significance of white mat ter high intensity lesions as a predictor of stroke from arteriolo- sclerosis[J ]. Neurol Neurosurg Psychiatry, 2002,72 ( 5 ) : 576- 582.
  • 3Verrneer SE, Hollander M, Van Dijk EJ, et al. Silent brain in- farcts and white matter lesions inereasestroke risk in the gener- alpopulation~ the Rotterdam Scan Study [J]. Stroke, 2003,34: 1 126-1 129.
  • 4Mcilroy SP, Dyaan KB, Lawson JT, et al. Moderately elevated plasma homoeysteine, methylenetetrahydro{olate reductase genotype,and rist forstroke, vascular dementia, and Alzheimer disease in Northern Ireland[J].Stroke,2002,33(10)~2 351- 2 356.
  • 5Wald DS,Saw M, Morris JK. Homocysteine and cardiovascular disease:evidence on causality {rom a meta-analysis[J]. BMJ, 2002,325(7 374) :1 202.
  • 6Jokinen H, Kalska H, Ylikoski R, et al. MRI-defined subcorti- calischemic vascular disease~ baseline clinical and neuropsycho- logicalfindings. The LADIs study[J'], cerebrovasc Dis, 20()9,27 (4) :336-344.
  • 7Ahamad Hassan, Beverley J, Hunt, et al. Homoeysteine is a rist factor for cerebral ssmall vessel disease, acting via endothelial dysfunctionEJ3. Brain, 2003,127 : 212-219.
  • 8Feng C, Bai X, Xu Y, et al. Hyperhomocysteinemia associates with small vessel disease more closely than large vessel disease [J]. Int J Med Sci,2013,10(4) ~408-412.
  • 9Khan U, Crossley C, Kalra L, et al. Homocysteine and its rela- tionshipto stroke subtypes in a UK black population: the south Londonethnicity and stroke study[J]. Stroke, 2008,39 : 2 943-2 949.
  • 10Naka H, Nomura E, Takahashi T, et al. Plasma total homo- cysteinelevels are associated with advanced leukoaraiosis but not with asympton-ntic microbleeds T ~ -weighted MRI in pa- tients with stroke[J]. Eur J Neurol, 2006,13 : 261-265.

二级参考文献28

  • 1Schmidtke K, Hull M. Cerebral small vessel disease: how does it progress? J Neural Sci, 2005,229-230 : 13-20.
  • 2Boiten J, Lodder J, Kessels F. Two clinically distinct lacunar infarct entities? A hypothesis. Stroke, 1993,24:652-656.
  • 3O'Sullivan M, Lythgoe DJ, Pereira AC, et al. Patterns of cerebral blood flow reduction in patients with ischemic leukoaraiosis. Neurology, 2002,59 : 321-326.
  • 4Terborg C, Gora F, Weiller C, et al. Reduced vasomotor reactivity in cerebral microangiopathy: a study with near-infrared spectroscopy and transeranial Doppler sonography. Stroke, 2000, 31:924-929.
  • 5Ringelstein EB, Nabavi DG. Cerebral small vessel diseases: cerebral mieroangiopathies. Curr Opin Neurol,2005,18 : 179-188.
  • 6Arboix A, Martl-Vilalta JL. Lacunar stroke. Expert Rev Neurother, 2009,9 : 179-196.
  • 7Fisher CM. Lacunar strokes and infarcts: a review. Neurology, 1982,32:871-876.
  • 8Lammie GA. Pathology of small vessel stroke. Br Med Bull, 2000, 56:296-306.
  • 9Arboix A, Marti-Vilalta JL. New concepts in lacunar strokeetiology : the constellation of small-vessel arterial disease. Cerebrovasc Dis,2004,17 Suppl 1:58-62.
  • 10Wardlaw JM, Sandercock PA, Dennis MS,et al. Is breakdown of the blood-brain barrier responsible for lacunar stroke, leukoaraiosis, and dementia? Stroke ,2003,34:806-812.

共引文献39

同被引文献84

  • 1李洁,刘妍君.缺血性脑卒中并脑微出血的相关因素分析[J].中国动脉硬化杂志,2015,23(2):180-184. 被引量：19
  • 2陈蓓,王耀山.皮质下动脉硬化性白质脑病[J].实用内科杂志,1989,9(10):545-547. 被引量：32
  • 3各类脑血管疾病诊断要点[J].中华神经科杂志,1996,29(6):379-380. 被引量：33024
  • 4Amytis Towfighi,Daniela Markovic,Bruce Ovbiagele.Pronounced association of elevated serum homocysteine with stroke in subgroups of individuals: A nationwide study[J].Journal of the Neurological Sciences.2010(1)
  • 5Tsutomu Sasaki,Manabu Watanabe,Yoji Nagai,Taku Hoshi,Masashi Takasawa,Masaru Nukata,Akihiko Taguchi,Kazuo Kitagawa,Naokazu Kinoshita,Masayasu Matsumoto.Association of Plasma Homocysteine Concentration With Atherosclerotic Carotid Plaques and Lacunar Infarction[J].Stroke: Journal of the American Heart Association.2002(6)
  • 6A New Rating Scale for Age-Related White Matter Changes Applicable to MRI and CT[J]. Stroke: Journal of the American Heart Association . 2001 (6)
  • 7Arani Nitkunan,Silvia Lanfranconi,Rebecca A. Charlton,Thomas R. Barrick,Hugh S. Markus.??Brain Atrophy and Cerebral Small Vessel Disease: A Prospective Follow-Up Study(J)Stroke . 2011 (1)
  • 8Loffredo Lorenzo,Violi Francesco,Fimognari Filippo Luca,Cangemi Roberto,Sbrighi Pier Sandro,Sampietro Francesca,Mazzola Giuseppina,Di Lecce Vito Nicola,D’Angelo Armando.The association between hyperhomocysteinemia and ischemic stroke in patients with non-valvular atrial fibrillation. Haematologica . 2005
  • 9Hachinski VC,Potter P,Merskey H.Leuko-araiosis. Archives of Neurology . 1987
  • 10A.M. Pavlovic,T. Pekmezovic,R. Obrenovic,I. Novakovic,G. Tomic,M. Mijajlovic,N. Sternic.??Increased total homocysteine level is associated with clinical status and severity of white matter changes in symptomatic patients with subcortical small vessel disease(J)Clinical Neurology and Neurosurgery . 2011 (9)

引证文献8

二级引证文献51

中国实用神经疾病杂志
2014年 第24期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部