Hedgehog信号通路对胸腺T细胞分化发育的影响

Roles of Hedgehog signaling in T cell differentiation and development

胸腺产生成熟功能性T细胞需要来自胸腺内多种信号如Wnt、Notch及Hedgehog等.Hedgehog家族不仅参与胚胎发育、组织及器官形成,近年来发现其与多种肿瘤的发生有着密切的联系.胸腺T细胞分化发育异常可能会引起各种免疫疾病以及肿瘤的发生.阐明Hedgehog信号通路对胸腺T细胞分化发育的影响对于肿瘤的治疗具有理论指导作用.

The production of mature functional T cells requires many signals from the thymus such as Wnt,Notch and Hedgehog,et al.The Hedgehog protein family signals for development,patterning and organogenesis of many tissues during mammalian embryogenesis.In recent years,more and more research groups focus their attention on it because of its relationship between tumors.Abnormal differentiation and development of T cells may cause various immunological diseases and tumors.Illuminating the roles of Hedgehog signaling in T cell differentiation and development can provide a theoretical guide in the treatment of tumor.