卵巢早衰49例临床分析

Clinical Analysis of 49 Women Premature Ovarian Failure

目的：了解卵巢早衰患者的临床特点及探讨治疗方案。方法对49例卵巢早衰患者的临床资料进行分析。结果5例POF患者有家族史，占10.2%，6例患过腮腺炎占18.4%。49例患者经雌孕激素治疗3~6个周期后，血清卵泡刺激素（FSH）、黄体生成素（LH）水平明显下降（ P〈0.01），血清雌二醇（E2）与服药前相比无显著性（P〉0.05），且经排卵治疗有2例足月妊娠。结论遗传因素和感染因素在POF的发病中占一定地位，但大部分为原因不明，经HRT治疗可缓解症状、预防并发症。

Objective To explove clinical fcature and investigate the treatment of patients with premature ovarian failure. Methods 49 patients with premature ovarian failure were evaluated from 2010 to 2013. Results 5（10.2%）cases had family history of POF, 6 （18.4%）case had parotiditis.49 patients with POF were treated by HRT for 3 to 6 cycles,the scram FSH、LH level of 49 patients with re？covery of mensc dropped sighficantly（P〈0.01）, while E2 raised slightly（P〉0.05）. Schemcs of ovarian were applicd in these patients, to two case were born after the normal period of gestion. Conclusion Genetic and infection disorders are the main causes of POF, but its reason are unknown in most cases. HRT isneeded to alleviate symptom to prevent longterm health scqucl of estrogen delicicncy.