活血化瘀抑制高龄骨伤患者全身炎性反应的临床研究

Clinical Research of Promoting Blood Circulation for Removing Blood Stasis in Bone-injury Geriatrics Inhibit Inflammation Reaction

目的：证实活血化瘀可有效减轻老年骨伤患者全身炎性反应。方法：选择年龄≥70岁髋部骨折拟行择期手术患者120例,随机分为研究组和对照组各60例。研究组患者入院后实施活血化瘀治疗直至术后10天,测定入院当天（T0）、手术当日（T1）及术后10天（T2）血液中白细胞（WBC）、中性粒细胞（NEUT）计数、伤口感染率、全身感染性疾病发生率及抗生素使用时间。结果：两组T1和T2WBC、NEUT计数及异常率明显低于T0（P〈0.05）,对照组T1NEUT计数及异常率明显高于研究组（P〈0.05）,余无统计学差异（P〉0.05）。两组患者术后并发感染性疾病发生率无统计学差异,与患者年龄段有关,70~79岁〈80~89岁〈90~100岁（P〈0.05）。结论：活血化瘀可有效抑制机体炎性反应,减少抗生素使用时间。

Objective： To confirm to promote blood circulation for removing blood stasis in bone-injury geriatrics could inhibit inflammation reaction. Methods： 120patients （age ≥70y） that were suffering hip fracture were randomly divided into two groups before operation： controlled group （n = 60） and invest group （n = 60）. Patients in the invest group received therapy of promoting blood circulation for removing blood stasis when admission hospital, and till 10days after operation. WBC, NUET, wound infection rate, systemic infection rate and time antibiotics used were measured at the time of admission （T0）, operation （T1）, 10days after operation （T2）. Results： Numbers of WBC, NEUT and of both two groups at time Tland T2were significantly lower than time TO （P〈0.05）. NEUT numbers of the controlled group was higher than that of the invest group （P〈 0. 05 ）. Differences of systemic infection rate between these two groups had not been found, that depended on age of patients, 70 79y〈80 - 89y〈90 - 100y （P〈0. 05 ）. Conclusion： Promoting blood circulation for removing blood stasis can inhibit inflammation reaction and shorten time antibiotic using.