常用非典型抗精神病药物与首发精神分裂症患者代谢综合征的相关性研究

Correlation Analysis on the Atypical Antipsychotic Drugs and Metabolic Syndrome of the Patients with First Occoured Schizophrenia

目的:探讨常用非典型抗精神病药物与首发精神分裂症患者代谢综合征的相关性。方法:随访调查单一使用抗精神病药物的首发精神分裂症患者147人,按用药不同,分为非典型抗精神病药物组患者92例,氯丙嗪组55例,测量患者使用抗精神病药物前和使用一年后的BMI、血压、血糖等指标。结果:两组均有病例发生了腹部肥胖、BMI≥24、糖尿病、糖耐量异常、高甘油三脂血症、低HDL血症、高血压、代谢综合征;两组病例在BMI≥24、高血压上有统计学差异(χ2=4.307,P=0.038;χ2=6.857,P=0.009),且氯丙嗪组患者更容易发生BMI≥24、高血压。两组病例在BMI、糖化血红蛋白、舒张压、收缩压方面有统计学差异(t=2.319,P=0.022;t=2.291,P=0.024;t=2.406,P=0.019;t=2.109,P=0.039)。结论:常用非典型抗精神病药物与首发精神分裂症患者代谢综合征的的发生具有相关性。

Objective：To explore the correlationship between the atypical antipsychotic drugs and meta-bolic syndrome of the patients with first occoured schizophrenia .Method： A total of 147 patients who first occoured schizophrenia and used one antipsychotics were followed in the investigation , according to use the different drugs , they were divided into two groups , the atypical antipsychotic drugs group contained 92 pa-tients and the chlorpromazine group contained 55 patients .They were measured BMI , blood pressure , plasma glucose and other indicators before and one year after using antipsychotic drugs .Result：The patients in both groups had the abdominal obesity , BMI≥24, diabetes, impaired glucose tolerance, high glycerin three grea-ses, low HDL level , hypertension , metab-olic syndrome .There were significant difference between the two groups in BMI≥24 and hypertension（χ^2=4.307,P=0.038;χ^2=6.857,P=0.009）, and there were more pa-tients in the chlorpromazine group who had BMI≥24 and hypertension;there were also significant difference between the two groups in BMI , glycosylated hemoglobin , diastolic blood pressure , systolic blood pressure （ t =2.319,P=0.022;t=2.291,P=0.024;t=2.406,P=0.019;t=2.109,P=0.039）.Conclusion：There＇s correlationship between the atypical antipsychotic drugs and the first occoured schizophrenia patients who hap -pened the metabolic syndrome .