江苏地区健康人群中3种免疫球蛋白的参考值调查

Investigation of IgG,IgA,IgM reference range in healthy crowd in Jiangsu area

目的建立江苏地区健康人群免疫球蛋白G(IgG)、免疫球蛋白A(IgA)、免疫球蛋白M(IgM)的参考范围。方法对江苏地区2 245名健康人的血清IgG、IgA、IgM进行检测,对结果进行统计分析。结果 (1)IgA参考范围为(2.04±0.85)g/L,其中男性(2.06±0.85)g/L,女性(2.03±0.86)g/L,不存在性别差异(P>0.05);IgG、IgM参考范围分别为(12.67±2.79)g/L、(1.83±0.94)g/L,其中男性IgG、IgM参考范围分别为(12.06±2.56)g/L、(1.45±0.71)g/L,女性IgG、IgM参考范围分别为(13.20±2.88)g/L、(2.16±0.99)g/L,女性IgG、IgM明显高于男性(P<0.05)。(2)灌云地区IgG明显高于姜堰和昆山地区(P<0.05),昆山地区IgA明显高于姜堰和灌云地区(P<0.05),姜堰和灌云地区IgM略高于昆山地区(P>0.05)。(3)男女各年龄阶段IgG、IgA、IgM的参考范围存在不同程度差异。结论 (1)江苏地区健康人群IgG、IgA、IgM的参考范围在性别、年龄组间是不同的。(2)旧的参考范围已不适用于当今人群,各地区、各实验室应制订本地区、本实验室的参考范围。若存在性别差异,应分别制订两性的参考范围。若存在年龄组间差异,还应进一步制订两性各年龄组的参考范围。

Objective To establish the IgG ,IgA ,IgM reference range in healthy crowd in Jiangsu area .Meth‐ods Serum IgG ,IgA ,IgM in 2 245 healthy individuals in Jiangsu area were tested and the detection results were ana‐lyzed statistically .Results （1）The reference range of IgA was（2 .04 ± 0 .85） g/L ,in which（2 .06 ± 0 .85）g/L for males and（2 .03 ± 0 .86）g/L for females without gender difference（P〉0 .05）;the average reference ranges of IgG and IgM were（12 .67 ± 2 .79）g/L and（1 .83 ± 0 .94）g/L respectively ,in which（13 .20 ± 2 .88）g/L and（2 .16 ± 0 .99） g/L） for females and（12 .06 ± 2 .56）g/L and（1 .45 ± 0 .71）g/L for males ,females was significantly higher than males with statistical differences （P〈0 .05） .（2）The average IgG level in Guanyun area was significantly higher than that in Jiangyan and Kunshan areas（P〈0 .05） ,the IgA level in Kunshan area was significantly higher than that in Jiangyan and Guanyun areas（P〈0 .05） ,the IgM level in Jiangyan and Guanyun areas was slightly higher than that in Kunshan area（P〉0 .05） .（3）The different degrees of difference in the IgG ,IgA ,IgM reference ranges existed among various age groups in males and females .Conclusion （1）The reference ranges of IgG ,IgA ,IgM in healthy crowd in Jiangsu area are different among various age groups and gender groups .（2）The old reference ranges are unsuitable for the nowadays crowds ,the different regions and different laboratories should formulate themselves reference ranges .If the gender difference exists ,the reference ranges of two genders should be respectively formulated .If the age group differences exist ,the reference ranges of the various age groups for two genders should be further formulated .