比较FX60和FX80透析器对血液透析患者并发症的影响

Application of FX60 and FX80 dialyzer on complications in maintenance hemodialysis patients

目的比较维持性血液透析患者应用不同高通量透析器的并发症情况。方法将58例透析时间大于2年的稳定血液透析患者分成两组,分别应用FX60和FX80透析器半年,比较它们对毒素的清除率及对慢性并发症的影响。结果 FX60和FX80透析器清除血肌酐、尿素氮差异无统计学意义(P>0.05)。单次应用FX60和FX80 i PTH的清除率分别为(0.30±0.02)%和(0.36±0.04)%,差异有统计学意义(P<0.05)。应用FX60透析器半年后血肌酐显著升高(P<0.05),应用FX80透析器半年前后患者尿素氮、i PTH、血红蛋白、心胸比的差异有统计学意义(P<0.05)。结论 FX60和FX80透析器对小分子物质的清除差异无统计学意义,但对中大分子的清除,FX80要显著优越于FX60。FX80透析器较FX60透析器能更好地改善肾性贫血、心功能和继发性甲状旁腺功能亢进。

[Objective] To compare different dialyzer on complications in maintenance hemodialysis patients. [Methods] A total of 58 patients on maintenance hemodialysis for more than 2 years were divided into two groups, were applied with FX60 and FX80 dialyzer for six months, Compare their application on clearance rate and chronic complications. [Results] FX60 and FX80 dialyzer cleared serum creatinine, urea nitrogen was no significant difference （P〉0.05）. After application FX60 dialyzer for six months the serum creatinine was significantly increased （P〈0.05）. After the application FX80 dialyzer for six months, the BUN, iPTH, HB, cardiothoracic ratio was statistically significant （P〈0.05）. [Conclusion] FX60 and FX80 dialyzer is no significant difference in the clearance of small molecules, but FX80 was significantly better than FX60 in clearance of macromolecules. FX80 dialyzer is better than FX60 dialyzer in renal anemia, heart function and secondary hyperparathyroidism.