质子泵抑制剂致不良反应的相关因素研究

Related Factors proton pump inhibitor-induced adverse reactions

目的：分析研究质子泵抑制剂不良反应的相关因素。方法：通过查阅国内外相关文献资料的形式,来进行质子泵抑制剂致不良反应相关因素的分析。并将随机抽取2012年5月~2014年3月到广东某医院就诊的100例消化性溃疡病患者作为研究对象,随机分为观察组（n=50）和对照组（n=50）;给予对照组患者雷尼替丁治疗,给予观察组患者奥美拉唑治疗;比较两组患者不良反应的发生率以及治疗效果。结果：质子泵会对身体各个器官或组织造成不同程度的伤害,甚至会出现严重不良反应的情况;观察组患者的不良反应发生率明显高于对照组,组间比较差异具有统计学意义P〈0.05;观察组患者的治疗有效率明显高于对照组,组间比较差异具有统计学意义P〈0.05。结论：质子泵抑制剂虽治疗效果显著,但引发患者出现药品不良反应的几率较高,因此要不断加大对于质子泵抑制剂的使用安全性以及可能发生的不良反应情况的观察研究力度。

Objective：Analysis of proton pump inhibitors adverse reactions related factors.Methods：After a review of relevant literature in the form of domestic and foreign,to analysis of proton pump inhibitors cause adverse reactions related factors.And randomly selected in May 2012~March 2014 to a hospital for treatment of 100 cases of peptic ulcer Guangdong patients as research subjects,Were randomly divided into two groups（n=50）and control group（n=50）;Ranitidine treatment given to patients in the control group;Given omeprazoletreated patients in the observation group;Probability of occurrence and treatment of patients with adverse reactions were compared.Results：Proton pump various body organs or tissues will cause varying degrees of damage,there may even be serious adverse reactions;Adverse reactions observed in patients was significantly higher probability of occurrence,the differences between the two groups was statistically significant P〈0.05;Treatment of patients in the observation group was significantly higher efficiency,the difference between groups was statistically significant P〈0.05;Conclusions：Although proton pump inhibitor therapy effect is remarkable,but the probability of adverse drug reactions in patients with raised higher,so to continue to increase the use of proton pump inhibitors for safety and adverse reactions may occur observation research efforts.