盐酸伐昔洛韦片和阿昔洛韦注射液治疗带状疱疹的临床疗效比较

Comparison on clinical efficacy between Valaciclovir Hydrochloride Tablets and Aciclovir Injection in treatment of herpes zoster

目的比较盐酸伐昔洛韦片和阿昔洛韦注射液治疗带状疱疹的临床疗效和安全性。方法选取上海市皮肤病医院2012年2月—2014年1月收治的带状疱疹患者100例,随机分为治疗组和对照组,每组各50例。治疗组口服盐酸伐昔洛韦片,2片/次,2次/d;对照组静脉滴注阿昔洛韦注射液加入250 m L 0.9%生理盐水中,5 mg/kg,2次/d。两组均连续治疗8 d。观察并记录两组患者的临床疗效和不良反应。结果治疗后,治疗组和对照组的总有效率分别为98%、96%,两组比较差异无统计学意义。两组患者皮损停止进展时间、开始结痂时间、一半皮疹结痂时间、所有皮疹脱痂时间和开始出现无疼痛时间相比差异无统计学意义。治疗组疼痛完全消失时间显著短于对照组,两组比较差异有统计学意义(P<0.05)。治疗组后遗神经痛的发生率低于对照组,两组比较差异有统计学意义(P<0.05)。结论盐酸伐昔洛韦片治疗带状疱疹具有较好的临床疗效,可以有效缩短疼痛时间,减少后遗神经痛的发生,值得临床推广使用。

Objective To compare the clinical efficacy and safety between Valaciclovir Hydrochloride Tablets and Aciclovir Injection in the treatment of herpes zoster. Methods Herpes zoster patients（100 cases） who came to Shanghai Dermatology Hospital from February 2012 to January 2014 were randomly divided into control and treatment groups, and each group had 50 cases. The patients in the treatment group were po administered with Valaciclovir Hydrochloride Tablets, 2 tablets/time, twice daily. The patients in the control group were iv administered with Aciclovir Injection adding into 250 m L of 0.9% saline solution, 5 mg/kg, twice daily. The patients in the two groups were treated for 8 d. The clinical efficacy and adverse reactions in two groups were observed and recorded. Results After treatment, the efficacies in the treatment and control groups were 98% and 96%, respectively, with no difference between the two groups. There was no statistically significant difference between two groups about the time of disease stopping, time of scab beginning, time of half rash scabbing, time of all rash scab off, and time of no pain beginning. The pain disappearing time in the treatment group was significantly shorter than that in the control group, with differences between the two groups（P〈0.05）. The incidence of legacy neuralgia in the treatment group was lower than that in the control group, with differences between the two groups（P〈0.05）. Conclusion Valaciclovir Hydrochloride Tablets have the good clinical effect in treatment of herpes zoster, and can effectively shorten the pain time and reduce the incidence of legacy neuralgia, which is worth clinical promotion.