哌拉西林钠舒巴坦钠持续静滴治疗重症肺炎的疗效观察

Clinical observation of piperacillin and sulbactam sodium continuous iv drip in treatment of severe pneumonia

目的探讨哌拉西林钠舒巴坦钠持续静滴治疗重症肺炎的临床疗效和安全性。方法选取2012年6月—2014年2月内蒙古林业总医院收治的重症肺炎90例,随机分为治疗组(46例)和对照组(44例)。治疗组患者首先给予注射用哌拉西林钠舒巴坦钠5.0 g溶入到200 m L生理盐水中,1 h内静滴完,然后将注射用哌拉西林钠舒巴坦钠5.0 g溶入至20 m L生理盐水中,将微量泵泵入速度调整为2 m L/h持续泵入,2次/d。对照组静脉滴注注射用哌拉西林钠舒巴坦钠5.0 g溶入至200m L生理盐水中,1 h静滴完,每8小时一次。两组均持续治疗3 d以上。比较两组的临床疗效,同时比较两组咳嗽消失时间、啰音消失时间、体温恢复正常时间、白细胞恢复正常时间。结果治疗后,治疗组和对照组的总有效率分别为80.44%、59.09%,两组总有效率比较差异有统计学意义(P<0.05)。治疗组咳嗽消失时间、啰音消失时间、体温恢复正常时间、白细胞恢复正常时间均显著短于对照组,两组比较差异有统计学意义(P<0.05)。结论哌拉西林钠舒巴坦钠持续静滴对重症肺炎有较好的临床疗效,可缩短各观察指标的时间,值得临床推广应用。

Objective To investigate the clinical effect of piperacillin and sulbactam sodium continuous iv drip in treatment of severe pneumonia. Methods Patients（90 cases） with severe pneumonia from June 2012 to February 2014 in the Inner Mongolia Forestry General Hospital were randomly divided into treatment（46 cases） and control（44 cases） groups. The patients in the treatment group were iv administered with Piperacillin and Sulbactam Sodium for injection 5.0 g adding into 200 m L 0.9% saline solution in 1 h, then diluted with 20 m L physiological saline continuous iv pump infusion, and the pumping speed was adjusted at 2 m L/h, twice daily. The patients in the control group were iv administered with Piperacillin and Sulbactam Sodium for injection 5.0 g adding into 200 m L 0.9% saline solution in 1 h, every 8 h/time. The patients in the two groups were treated for more than 3 d. After the treatment, the efficacy was evaluated, while the time of cough disappeared, rale disappear time, body temperature returned to normal time, and white blood cells back to normal time in two groups were compared. Results The efficacies in the treatment and control groups were 80.44% and 59.09%, respectively, and there were differences between two groups（P〈0.05）. The time of cough disappeared, rale disappear time, body temperature returned to normal time, and white blood cells back to normal time in treatment group were shorter than those in the control group, and there were differences between two groups（P〈0.05）. Conclusion Piperacillin and sulbactam sodium continuous iv drip has good clinical effect in treatment of severe pneumonia, and can shorten the time of observational indexes, which is worth of clinical promotion.