杜仲叶化学成分研究

Study on Chemical Constituents of Eucommia ulmoides Leaves

目的:研究杜仲叶的化学成分。方法:采用各种柱色谱方法分离纯化,通过理化常数测定和光谱分析鉴定化合物结构。结果:从杜仲叶中分离鉴定了10个化合物,分别为:borreriagenin(1)、正丁基-O-β-D-吡喃果糖苷(2)、α-D-吡喃葡萄糖基-(1→1')-3'-氨基-3'-去氧-β-D-吡喃葡萄糖苷(3)、β-D-呋喃果糖基-α-D-吡喃半乳糖苷(4)、β-D-果糖(5)、邻苯二甲酸二异丁酯(6)、5-羟基-9-异丙基-愈创木基丙三醇(7)、4-羟基苯乙醇-8-O-β-D-芹糖基(1→6)-β-D-葡萄糖苷(8)、落叶松脂醇(9)、(3S,5R,6R,9S)-四羟基-7-烯-大柱烷(10)。结论:所有化合物均为首次从该属植物中分离得到。

Objective： To investigate the chemical constituents of Eucommia ulmoides leaves. Methods： Various column chromatography were used in the isolation and purification,physiochemical constant determination and spectral analysis were adopted to determine the chemical structures. Results： Ten compounds were isolated and identified as borreriagenin（1）,n-butyl-O-β-D-fructopyranoside（2）,α-D-glucopyranosyl-（1→1＇）-3＇-amino-3＇-deoxy-β-D-glucopyranoside（3）,β-D-fructofuranosyl-α-D-galactopyranoside（4）,β-D-fructose（5）,diisobutyl phthalate（6）,5-hydroxy-9-isopropylether-guaiacylglycerol（7）,4-hydroxyphenylethanol-8-O-β-D-apiofuranosyl（1→6）-β-D-glucopyranoside（8）,lariciresinol（9）,and（3S,5R,6R,9S）-tetrahydroxy-7-ene-megastigmane（10）. Conclusion： All compounds are isolated from this genus for the first time.