ODC G316A多态性与乳癌患者生存的关系

Relationship between ODC G316A polymorphism and breast cancer survival

目的：观察ODC G316 A多态性与乳癌患者生存的关系，旨在为乳癌患者的筛查、预防和治疗提供新的靶点。方法：收集150例乳癌患者的术后蜡块，采用巢式PCR-RFLP方法进行ODC G316 A的分型（ AA、AG和GG），并进行生存分析。结果：150例患者中，ODC G316 A AA/AG型72例，ODC G316 A GG型78例。 ODC G316 A GG患者比ODC G316A AA/AG患者具有更长的生存时间[109．7（86．0～128．0）个月 vs 100．6（78．0～122．0）个月；χ^2＝9．567，P＝0．002]。Ⅰ期患者至随访结束无死亡病例；Ⅱ期患者中，ODC G316A GG与ODC G316A AA/AG患者的中位生存时间差异无统计学意义[117．2（88．0～130．0）个月 vs 111．8（48．0～130．0）个月；χ^2＝0．012，P＝0．914]；Ⅲ期患者中，ODC G316A GG患者比ODC G316A AA/AG患者具有更长的生存时间[124．0（68．0～124．0）个月 vs 100．0（46．0～100．0）个月；χ^2＝5．187，P＝0．023]。结论：ODC G316A多态性与乳癌患者的生存期有关，可能成为未来乳癌治疗的一个新的潜在预防和治疗靶点。

Aim：To explore the association between ODC G 316 A single nucleotide polymorphism with the survival of patients with breast cancer ,so as to provide a new target for screening ,preventing and treating of breast cancer .Methods：The samples from 150 patients with breast cancer were used for genotyping of ODC G 316A by PCR-RFLP.The survival sta-tus of all the patients were recorded .Results：In 150 patients with breast cancer ,there were 72 with ODC G316A AA/AG genotype,and 78 with ODC G316A GG genotype.The patients with ODC G316A GG genotype had longer survival time than those with ODC G316A AA/AG[109.7（86.0 -128.0） months vs 100.6（78.0 -122.0） months;χ2 =9.567,P =0.002].None of the patients at stage Ⅰdied during the follow-up.Among the patients at stage Ⅱ,those with ODC G316A GG genotype had similar survival time as those with ODC G316A AA/AG[117.2（88.0 -130.0） months vs 111.8 （48.0-130.0） months;χ^2 =0.012,P=0.914];among the patients at stage Ⅲ,those with ODC G316A GG genotype had longer survival time than those with ODC G316A AA/AG[124.0（68.0 -124.0） months vs 100.0（46.0 -100.0） months;χ^2 =5.187,P=0.023].Conclusion：It is implicated that ODC G316A polymorphism may be associated with the survival of patients with breast cancer .