胃腺癌组织中Lgr5和Wnt1蛋白的表达

Expressions of Lgr5 and Wnt1 in gastric adenocarcinoma tissue

目的:检测胃腺癌组织中Lgr5和Wnt1蛋白的表达。方法:采用免疫组化SP法检测76例胃腺癌组织及30例癌旁正常胃组织中Lgr5和Wnt1蛋白的表达。结果:Lgr5和Wnt1蛋白在胃腺癌组织中的阳性表达率高于癌旁正常胃组织(χ2=16.332和14.609,P均<0.05)。Lgr5和Wnt1蛋白的表达与胃腺癌的大小、TNM分期、分化程度以及淋巴结转移情况有关(P均<0.05)。胃腺癌组织中Lgr5和Wnt1蛋白的表达呈正关联(rP=0.329,P=0.002)。结论:Lgr5和Wnt1蛋白在胃腺癌的发生、分化、浸润和转移中起重要作用,有望成为胃腺癌早期诊断的指标和治疗靶点。

Aim：To detect the expressions of Lgr 5 and Wnt1 in gastric adenocarcinoma tissue .Methods：The expres-sions of Lgr5 and Wnt1 were detected by immunohistochemistry in 76 cases of gastric adenocarcinoma and 30 cases of nor-mal gastric tissue near the cancer .Results：The positive expression rates of Lgr 5 and Wnt1 in gastric adenocarcinoma tissue were significantly higher than those in normal gastric tissue near the cancer （χ^2 =16.332 and 14.609,P〈0.05）.The ex-pressions of Lgr5 and Wnt1 were related with the size of the tumor ,TNM stage,histopathological grade and lymph node me-tastasis（P〈0.05）.There was positive association between the expression of Lgr 5 and that of Wnt1 in gastric adenocarcino-ma tissue（rP =0.329,P=0.002）.Conclusion：Lgr5 and Wnt1 might play important roles in the carcinogenesis ,differenti-ation,infiltration,and metastasis of gastric adenocarcinoma ,and might be used as early diagnostic markers and therapeutic targets for gastric adenocarcinoma .