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索拉非尼联合放射治疗肝癌53例 被引量:1

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摘要 目的:探讨索拉菲尼联合放射治疗肝癌的临床疗效。方法:收集肝癌患者106例,随机分为两组各54例,实验组采用索拉菲尼联合放射治疗肝癌,而对照组则单用索拉菲尼治疗肝癌,通过对比治疗,比较两者的疗效。结果:观察组总有效率和疾病空置率均优于对照组,差异有统计学意义(P<0.05)。结论:索拉菲尼联合放射治疗可以有效提高肝癌的疗效,在临床上值得进一步研究和实践。
作者 查国华
出处 《长江大学学报(自科版)(下旬)》 CAS 2014年第12期78-79,共2页 Journal of Yangtze University
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  • 1DAL LAGO L, DHONDT V, AWADA A. Selected combination therapy with sorafenib: a review of clinical data and perspectives in advanced solid tumors [ J ]. Oncologist, 2008, 13 (8) :845 - 858.
  • 2GARNETT M J, MARAIS R. Guilty as charged: B-RAF is a human oncogene [ J ]. Cancer Cell,2004,6 (4) :313 - 319.
  • 3WILHELM S M, CARTER C,TANG L,et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis [ J ]. Can Res, 2004,64 ( 19 ) : 7099 - 7109.
  • 4LIU L,CAO Y,CHEN C ,et al. Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC /PRF/5 [ J ]. Can Res,2006,66(24) :11851 - 11858.
  • 5CLARK J W, EDER J P, RYAN D, et al. Safety and pharmacokinetics of the dualaction Raf kinase and vascular endothelial growth factor receptor inhibitor, BAY 43-9006, in patients with advanced, refractory solid tumors [ J ]. Clin Can Res, 2005,11 ( 15 ) : 5472 - 5480.
  • 6AWADA A, HENDLISZ A, GIL T, et al. Phase I safety and pharmacokinetics of BAY 43-9006 administered for 21 days on/7 days off in patients with advanced, refractory solid tumours[J]. Brit J Can , 2005,92(10) : 1855 - 1861.
  • 7MOORE M, HIRTE H W, SIU L, et al. Phase 1 study to determine the safety and pharmacokinetics of the novel Raf kinase and VEGFR inhibitor BAY 43-9006, administered for 28 days on/7 days off in patients with advanced, refractory solid tumors [J].Anna Onco 2005,16(10) :1688 - 1694.
  • 8STRUMBERG D, RICHLY H, HILGER R A,et al. Phase Ⅰ clinical and pharmacokinetic study of the novel Raf kinase and vascular endothelial growth factor receptor inhibitor BAY 43-9006 in patients with advanced refractory solid tumors [ J ]. J Clin Onco , 2005, 23 (5) :965 -972.
  • 9ABOU-ALFA G K, SCHWARTZ L, RICCI S, et al. Phase Ⅱ study of BAY 43-9006 in patients with advanced hepatocellular carcinoma [J].J Clin Onco, 2006, 24(26):4293- 4300.
  • 10YAU T, CHAN P, NG K K, et al. Phase Ⅱ open-label study of singleagent sorafenib in treating advanced hepatocellular carcinoma in a hepatitis B-endemic Asian population: presence of lung metastasis predicts poor response[J]. Cancer,2009,115 ( 2 ) :428 - 436.

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