Pirh2和Naked2在乳腺癌组织中的表达及其临床意义

The expression and clinical significance of Pirh2 and Naked2 in breast cancer

目的:分析乳腺癌组织中Pirh2和Naked2的表达情况及其临床意义。方法:随机选取在2011年1月—2013年12月期间收治的96例乳腺癌标本作为观察组,同时选取癌旁组织作为对照组,应用免疫组织化学方法对Pirh2和Naked2表达情况进行检测,分析Pirh2和Naked2表达与乳腺癌病理分级的关系及Pirh2和Naked2两者的相关性。结果:Pirh2在乳腺癌组织中高表达,癌旁组织中低表达,Naked2在乳腺癌组织中低表达,癌旁组织中高表达(P<0.05);年龄、肿瘤大小与癌中Pirh2和Naked2的表达无关(P>0.05);肿瘤病理分级和淋巴结转移与Pirh2和Naked2的表达相关(P<0.05);Pirh2和Naked2的表达呈负相关。结论:Pirh2和Naked2对乳腺癌的生物学行为的判断及预后有一定的提示作用。

Objective： To analyze the expression and clinical significance of Pirh2 and Naked2 in breast cancer. Methods： 98 breast cancer specimens from Jan.2011 to Dec.2013 were randomly selected as the observation group,while the adjacent tissues were selected as a control group. The immunohistochemistry method was used to detect the expression of Pirh2 and Naked2 in 96 breast cancer cases,analyze the pathology character,and then detect the relationship between them. Results：Pirh2 was highly expressed in breast cancer,lowly expressed in adjacent tissues. However Naked2 was lowly expressed in breast cancer tissues,highly expressed in adjacent tissues,the difference was significant（P〈0.05）. Age and tumor size were no significant difference between Pirh2 and Naked2 expression（ P〉 0. 05）. Pirh2 and Naked2 were correlated with tumor grade and lymph node metastasis（P〈0.05）. The expression of Pirh2 and Naked2 in breast cancer tissue was negative（P〈0.05）.Conclusion： Pirh2 and Naked2 has an important role in the breast cancer and has suggestive action in biological behavior and prognosis of breast cancer.