还原型辅酶Q10治疗重型复发性阿弗他溃疡的随机、对照试验研究

Reduced coenzyme Q10 in treatment of severe recurrent aphthous ulcer： a randomized, controlled trial

目的 观察还原型辅酶Q10治疗重型复发性阿弗他溃疡（RAU）的临床疗效.方法 将64例重型RAU患者按随机数字表法分为试验组（30例）与对照组（34例）.对照组予以常规治疗,试验组在对照组的基础上口服辅酶Q10,观察相关临床指标差异性.结果 与入院时比较,试验组入院2周汉密尔顿焦虑量表（HAMA量表）、疾病不确定量表（MUIS量表）、目测模拟疼痛程度指数（VAS指数）的评分显著降低,差异有统计学意义（P＜0.05）;与对照组入院2周比较,试验组MUIS量表、VAS指数的评分显著降低,差异有统计学意义（P＜0.05）;与入院时比较,试验组入院2周超氧化物歧化酶、CD4^＋、CD4^＋/CD5^＋显著升高,差异有统计学意义（P＜0.05）,丙二醛（MAD）、纤维蛋白原含量显著降低,差异有统计学意义（P＜0.05）;与对照组入院2周比较,试验组MAD含量显著降低,CD4^＋、CD4^＋/CD5^＋显著升高,差异有统计学意义（P＜0.05）;与对照组比较,试验组溃疡持续时间明显缩短[（13.75±3.58）d比（16.89±5.17）d],差异有统计学意义（P＜0.05）;与对照组比较,试验组的起效率明显增加、无效率明显下降、总有效率明显增加,差异均有统计学意义（P＜0.05）.结论 辅酶Q10治疗重型RAU疗效确切,值得临床推广.

Objective To observe the curative effect of reduced coenzyme Q10 in treatment of severe recurrent aphthous ulcer （RAU）.Methods A total of 64 severe RAU patients were divided into experimental group （30 cases） and control group （34 cases） by random digits table method.The control group received conventional treatment,and the experimental group was treated with coenzyme Q10 on the basis of the control group.The clinical indicators were observed.Results Compared to patients on admission,the Hamilton Anxiety Scale （HAMA scale）,disease uncertainty Scale （MUIS scale）,visual analog pain scale （VAS index） after 2 weeks in hospital in the experimental group were decreased,and there were significant differences （P 〈 0.05）.Compared to the control group after 2 weeks in hospital,MUIS scale,VAS index were decreased in the experimental group,and there were significant differences （P 〈 0.05）.Compared to patients on admission,superoxide dismutase,CD4^＋,CD4^＋/CD5^＋ after 2 weeks in hospital in the experimental group were increased,malondialdehyde （MAD）,fibrinogen were decreased,and there were significant differences （P 〈0.05）.Compared to the control group after 2 weeks in hospital,MAD was decreased,CD4^＋,CD4^＋/CD5^＋ were increased in the experimental group,and there were significant differences （P 〈0.05）.Compared to the control group,the ulcer duration in the experimental group was shorter [（13.75 ± 3.58） d vs.（16.89 ± 5.17） d],and there was significant difference （P 〈 0.05）.Compared to the control group,the efficiency was increased,the no efficiency was decreased,the total efficiency was increased,and there was significant difference （P 〈 0.05）.Conclusion Coenzyme Q10 is effective in treatment of severe RAU,worthy of promotion.