血清胱抑素C、尿微量白蛋白、尿β_2-MG检测在肝硬化患者中的应用价值

Values of Detection of Serum Cystatin C,Urine Micro-albumin,Urine β_2-Microglobin in Patients with Liver Cirrhosis

目的探讨血清胱抑素C(Cysc-C)、尿微量白蛋白(UmAlb)、尿β_2-MG(Uβ_2-MG)检测在肝硬化患者中的应用价值。方法应用免疫比浊法和酶联免疫法对61例肝硬化患者(其中31例无腹水,30例伴腹水)进行血清Cysc-C、UmAlb、Uβ_2-MG水平检测,并与35名正常健康人做比较。结果肝硬化患者血清Cysc-C、UmAlb、Uβ_2-MG水平均显著地高于正常人组(P<0.01)。肝硬化腹水组又明显高于无腹水组(P<0.01)。血清Cysc-C水平与UmAlb、Uβ_2-MG水平呈显正相关(r=0.6011、0.5984,P<0.01)。结论血清Cysc-C、UmAlb、Uβ_2-MG均具有较好的反映肝硬化患者早期肾损伤的诊断价值。

Objective To explore the values of serum cystatin C （ Cys- C ）, Urine Microalbuminand （UMAlb） and Urine β2-Microglobin （β2-MG） in Patients with liver cirrhosis. Methods The Serum Cys-C, umAlb （with immunoturbility assay） and Uβ2-MG（with ELISA） Levels were determined in 61 patients with liver cirrhosis （ 30 cases ascites the cirrhosis and 31 cases without ascites） and 35 healthy controls. Results The Serum Cys- C and UmAlb and β2-MG levels in patients were significantly higher than those in controls（ P 〈 0.01 ）. These markers in liver cirrhosis with aseites group were higher that that without ascites groups（ P 〈0.01 ）. Theserum Cys-C levels were positively correlated with UmAlb and Uβ2-MG levels（ r = 0. 6011,0. 5984, P 〈 0.01 ）. Conclusion The detection levels of serum Cys-C, UmALb and Uβ2-MG have important value in the early diagnosing renal function damage.