细菌性阴道病与宫颈上皮内瘤变、高危型乳头瘤病毒的关系研究

ASSOCIATION BETWEEN BACTERIAL VAGINOSIS AND CERVICAL INTRAEPITHELIAL NEOPLASIA AND HIGH-RISK HUMAN PAPILLOMA VIRUS

目的:探讨细菌性阴道病(BV)与宫颈上皮内瘤变(CIN)、高危型乳头瘤病毒的关系。方法:分析2007年2月至2010年12月期间就诊的185例CIN患者(CIN组)及正常妇女248例(对照组),分别统计各组病例中BV及HPV16/18感染的例数,分析BV的存在与CIN患者HPV16/18感染的关系。结果:185例CIN患者中,17例患者BV阳性,而248例正常人群中仅9例阳性,其差异有统计学意义(P<0.05)。CIN组106例HPV阳性,对照组仅12例阳性,两组HPV16/18感染率比较差异有统计学意义(P<0.001)。185例CIN患者中,BV及HPV均阳性者14例,HPV阳性BV阴性者95例,HPV阴性BV阳性者3例,两者比较差异有统计学意义(P=0.032)。结论:BV可能是CIN的高危因素,也可能是HPV感染致CIN的协同因素。

Objective：To determine whether the presence of bacterial vaginosis （BV） is associated with cervical intraepithelial neoplasia （CIN） and high-risk human papilloma virus （HPV） infection.Methods：A total of 185 women who had CIN and 248 normal women in our institute from February 2007 to December 2010 were selected for the screening tests for BV and HPV 16/18.Results：Seventeen out of 185 CIN patients were detected for BV positive while only 9 were found in 248 normal women.The incidence of BV and HPV16/18 infection was significantly higher in CIN than in normal groups.HPV16/18 infection showed significant relationship with BV in the CIN group.Conclusion：BV may be one of the risk factors for cervical intraepithelial neoplasia,and one of the cofactor for HPV to cause cervical intraepithelial neoplasia.